Systematic Detection of Adverse Drug Events Jerry Avorn INTRODUCTION & CASE CHALLENGES IN THE ASCERTAINMENT OF DRUG SAFETY Study Size and Generalizability Surrogate Outcomes and Comparators Duration and Postapproval Studies…
Pharmacology of the Thyroid Gland Anthony Hollenberg and William W. Chin INTRODUCTION & CASE THYROID GLAND PHYSIOLOGY Synthesis and Secretion of Thyroid Hormones Metabolism of Thyroid Hormones Effects of Thyroid…
Adrenergic Pharmacology Nidhi Gera, Ehrin J. Armstrong, and David E. Golan INTRODUCTION & CASE BIOCHEMISTRY AND PHYSIOLOGY OF ADRENERGIC FUNCTION Catecholamine Synthesis, Storage, and Release Reuptake and Metabolism of Catecholamines…
INTRODUCTION Our tissues are exposed on a daily basis to xenobiotics—foreign substances that are not naturally found in the body. Most drugs are xenobiotics that are used to modulate bodily…
Drug Transporters Baran A. Ersoy and Keith A. Hoffmaster INTRODUCTION & CASE UPTAKE AND EFFLUX TRANSPORTERS Uptake Transporters Organic Anion-Transporting Polypeptide (OATP) Family Organic Anion Transporter (OAT) Family Organic Cation…
INTRODUCTION Modern pharmacologic agents are used to treat or control diseases that range from hypertension to human immunodeficiency virus (HIV) infection. In many cases, the same drug regimens are used…
Cyberterrorism Brian Krakover INTRODUCTION In the past, most terrorist attacks have aimed to directly kill, injure, or intimidate a target group for political purposes. This has usually meant a bomb…
Mass Fatality Incidents Lynn Roppolo Kathy J. Rinnert INTRODUCTION A mass fatality incident is a situation resulting in loss of life that exceeds death investigation resources in the local community…
Agricultural Terrorism and its Implications for the Health Care System Timothy Rupp Shane Zatkalik INTRODUCTION The first thing that would catch your notice would be the withered crop in the…
The Forensic Evaluation of Gunshot Wounds Associated With a Terrorist Event William S. Smock The United States has been forever changed by the domestic and international terrorist events on our…
