Usually presents on scalp in infancy, often at birth Presents as yellowish flat to warty plaque; enlarges during puberty • Basaloid follicular hamartoma Usually presents in adults Microscopic • Nevus sebaceus Abnormalities…
Represent < 0.5% of all oral malignancies • Mean in 6th-7th decades • M > F (2.5-3:1) • Hard palate and maxillary alveolus are most common sites of involvement (~ 80%) • Cervical lymph…
Benign clear cell adnexal proliferation with external root sheath differentiation • Subtype: Desmoplastic tricholemmoma Etiology/Pathogenesis • Some cases are associated with Cowden syndrome (PTEN hamartoma syndrome) Multiple tricholemmomas, hamartomas, and visceral tumors…
Solitary form (myofibroma) Multicentric form (myofibromatosis) • Synonyms: Infantile myofibromatosis, congenital generalized fibromatosis Continuum with lesions termed myopericytoma and infantile hemangiopericytoma Clinical Issues • Most common from birth to 2 years • Most…
Local recurrences Metastases Microscopic • Epithelial islands with interspersed glands/ducts • Cells composing islands are variable Clear Poroid Squamoid (less common) Rarely mucinous • Hyalinized stroma Similar to hidradenoma • Infiltrative growth pattern Not…
Composed of enlarged cells with abundant clear to vacuolated-appearing cytoplasm • Chondroid melanoma Malignant epithelioid cells associated with prominent myxochondroid-appearing matrix • Osteoid melanoma Malignant epithelioid cells associated with prominent osteoid-appearing material…
Conjunctival Melanoma Presenting as Pigmented PatchClinical image shows an expansile pigmented patch at the limbus and adjacent to the iris . Bulbar conjunctiva close to the limbus is the most…
Embryonal, alveolar, pleomorphic, and epithelioid types of RMS have been described as primary cutaneous tumors Clinical Issues • Very rare Cutaneous metastases or secondary involvement of skin by deep primary must…
Clinical PhotographPhotograph shows a medium-sized infantile hemangioma on the face of a female infant. Most of these lesions are located in the head and neck region. (Courtesy J. Hall, MD.)…
