Paget Disease
Paget Disease Scott R. Owens, MD Key Facts Terminology Primary Perianal Paget disease not associated with underlying rectal or anal neoplasm Secondary Perianal Paget disease associated with adenocarcinoma of distal…
PATHOLOGY & LABORATORY MEDICINE
Condyloma, Anus
Condyloma, Anus Scott R. Owens, MD Key Facts Etiology/Pathogenesis Sexually transmitted disease HPV serotypes 6, 11 most common in anal condylomata Clinical Issues Increasing incidence (˜ 50% over past several…
Inflammatory Bowel Disease-Associated Neoplasia
Inflammatory Bowel Disease-Associated Neoplasia Julianne K. Purdy, MD Key Facts Macroscopic Features Polypoid dysplastic lesion/DALM Adenoma-like: Endoscopically resectable, dome-shaped, sharp borders Non-adenoma-like: Not endoscopically resectable, sessile/plaque-like, indistinct margins Microscopic Pathology…
Hemorrhoids
Hemorrhoids Julianne K. Purdy, MD Key Facts Terminology Hemorrhoids are normal submucosal vascular beds Hemorrhoidal disease when vessels dilate and symptoms develop Clinical Issues Internal hemorrhoids: Painless rectal bleeding External…
Carcinoid Tumor, Colon
Carcinoid Tumor, Colon Scott R. Owens, MD Key Facts Clinical Issues More commonly occurs in rectum than in remainder of colon Most are asymptomatic Local excision sufficient for small tumors…
Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer Syndrome)
Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer Syndrome) Joel K. Greenson, MD Key Facts Terminology Germline defect in 1 or more DNA mismatch repair enzymes, which leads to neoplasia Autosomal dominant…
Familial Cancer Syndromes in Colorectal Carcinoma
Familial Cancer Syndromes in Colorectal Carcinoma Joel K. Greenson, MD TERMINOLOGY Abbreviations Familial adenomatous polyposis (FAP) Adenomatous polyposis gene (APC) Hereditary nonpolyposis colorectal cancer (HNPCC) Definitions Familial cancer syndromes =…
Sessile Serrated Adenoma
Sessile Serrated Adenoma Alexandros D. Polydorides, MD, PhD Key Facts Terminology Serrated polyps: Saw-toothed epithelium (infolding) HP, TSA, SSA/P, mixed adenoma-serrated polyps Etiology/Pathogenesis Inhibition of apoptosis/exfoliation of surface mucosa “Serrated…
Mixed Adenoma-Serrated Polyp
Mixed Adenoma-Serrated Polyp Alexandros D. Polydorides, MD, PhD Key Facts Etiology/Pathogenesis Serrated path: HP → SSA/P → MASP → TSA → cancer? MSI, CIMP (MGMT, hMLH1), BRAF mutations Clinical Issues…
Ganglioneuroma
Ganglioneuroma Elizabeth A. Montgomery, MD Key Facts Terminology Neoplasm composed of mixture in variable proportions of spindled schwannian cells and ganglion cells Syndromic lesions associated with MEN2b, NF1, and FAP…
