Drug-related Granulomatous Hepatitis Laura Webb Lamps, MD Key Facts Clinical Issues Drug-induced hepatic injury can mimic any other form of liver disease Microscopic Pathology Noncaseating granulomas Presence of granulomas, ±…
Paucity of Intrahepatic Bile Ducts (Nonsyndromic) Joseph Misdraji, MD Key Facts Terminology Heterogeneous group of disorders that causes bile duct paucity in patients without congenital abnormalities indicative of Alagille syndrome…
Drug-related Acute Hepatitis Sanjay Kakar, MD Key Facts Etiology/Pathogenesis 2 chief mechanisms: Intrinsic and idiosyncratic Herbal and botanical drugs are important but often overlooked cause of hepatotoxicity Clinical Issues Classified…
Idiopathic Adulthood Ductopenia Joseph Misdraji, MD Key Facts Terminology Ductopenia in adult without known cause or clinicopathologic features of specific etiology Clinical Issues Presents with episodic jaundice and pruritus Can…
Idiopathic Neonatal Hepatitis Grace E. Kim, MD Key Facts Terminology Convenient term for clinical condition manifested by prolonged jaundice in neonates with variable but definable histologic picture Microscopic Pathology Predominately…
Primary Biliary Cirrhosis Matthew M. Yeh, MD, PhD Key Facts Terminology Idiopathic chronic cholestatic autoimmune liver disease in which intrahepatic bile ducts are progressively destroyed by nonsuppurative inflammation Clinical Issues…
Echinococcosis Kari D. Caradine, MD Key Facts Terminology Zoonosis caused by larval stages of cestodes of genus Echinococcus Etiology/Pathogenesis Humans infected accidentally by exposure to contaminated feces Clinical Issues Right…
Schistosomiasis Joseph Misdraji, MD Key Facts Terminology Hepatosplenic schistosomiasis is caused primarily by S. japonicum and S. mansoni Clinical Issues Cercariae exit snail, penetrate skin of vertebrate host, mature in…
Cryptococcosis Kari D. Caradine, MD Key Facts Terminology Infection by fungus Cryptococcus neoformans Usually hematogenously disseminated disease with multiorgan system involvement Etiology/Pathogenesis Found in soil, most abundant in avian habitats,…
