Hepatic Adenoma Matthew M. Yeh, MD, PhD Key Facts Etiology/Pathogenesis Almost always associated with oral contraceptive or long-term steroid use May regress after withdrawal of oral contraceptives Clinical Issues Typically…

Chronic Rejection Matthew M. Yeh, MD, PhD Key Facts Microscopic Pathology Atypical bile duct epithelium resembling dysplasia Centrizonal perivenular hepatocyte dropout Loss of interlobular bile duct Foam cell arteriopathy Luminal…

Acute Cellular Rejection Lisa Yerian, MD Key Facts Terminology Immune-mediated inflammation and injury of liver allograft due to genetic mismatch Etiology/Pathogenesis Inflammatory cells in portal tracts and centrilobular, perivenular areas…

Nodular Regenerative Hyperplasia Sanjay Kakar, MD Key Facts Etiology/Pathogenesis NRH results from changes in hepatic blood flow resulting from obliteration of small portal vein radicles Clinical Issues Symptomatic NRH clinically…

Amyloidosis Sanjay Kakar, MD Key Facts Etiology/Pathogenesis Liver involvement may be seen in AL, AA, and hereditary amyloidosis Microscopic Pathology Sinusoidal pattern is more common in AL amyloidosis and vascular…

Veno-occlusive Disease Sanjay Kakar, MD Key Facts Etiology/Pathogenesis Stem cell transplantation and high-dose chemotherapy Sinusoidal endothelial cell injury is important initial event Clinical Issues Hyperbilirubinemia, weight gain, and painful hepatomegaly…

Portal Venous Obstruction Laura Webb Lamps, MD Key Facts Etiology/Pathogenesis Can occur at any level of portal venous system Extrahepatic: Portal trunk or large tributaries, usually caused by thrombosis Intrahepatic:…

NASH Matthew M. Yeh, MD, PhD Key Facts Etiology/Pathogenesis Associated conditions Diabetes, obesity, hyperlipidemia, dyslipidemia, drugs, malabsorption, malnutrition Clinical Issues Patients often have metabolic syndrome Transaminases usually elevated May have…

Drug-related Steatohepatitis/Phospholipidosis Laura Webb Lamps, MD Key Facts Terminology Definition: Steatohepatitis as consequence of drug exposure Etiology/Pathogenesis Commonly implicated drugs Amiodarone Methotrexate Antiretroviral drugs Nifedipine Clinical Issues Symptoms may present…

Drug-induced Acute Hepatic Failure Sanjay Kakar, MD Key Facts Terminology Onset of hepatic encephalopathy within 8 weeks of onset of symptoms INR is > 1.5, and there is no evidence…