Lymphoepithelial Cysts Grace E. Kim, MD Key Facts Clinical Issues Rare nonneoplastic pancreatic cystic lesions composed of squamous epithelial and lymphoid elements Macroscopic Features Multilocular or unilocular cystic lesions Microscopic…

Diabetes Mellitus Laura Webb Lamps, MD Key Facts Terminology Heterogeneous group of metabolic diseases characterized by hyperglycemia, generally classified as types 1 and 2 Macroscopic Features Decreased size and weight…

Pseudocysts Vikram Deshpande, MD Key Facts Terminology Pancreatic or peripancreatic collection of fluid rich in pancreatic enzymes Etiology/Pathogenesis Occurrence parallels that of pancreatitis Alcoholic abuse is leading cause Macroscopic Features…

Autoimmune Pancreatitis Mari Mino-Kenudson, MD Key Facts Terminology Fibroinflammatory disease of presumed autoimmune etiology that affects pancreas Often elevated serum IgG4 Similar fibroinflammatory process often affects other organs such as…

Polyarteritis Nodosa and Other Vasculitides Laura Webb Lamps, MD Key Facts Etiology/Pathogenesis Liver and gallbladder involved in > 40% of cases of polyarteritis nodosa (PAN) Gallbladder involvement occasionally isolated rather…

Eosinophilic Cholecystitis Vikram Deshpande, MD Key Facts Terminology Inflammatory disease of gallbladder in which inflammatory infiltrate is composed predominantly of eosinophils Microscopic Pathology Dense eosinophilic infiltrate of gallbladder with or…

Xanthogranulomatous Cholecystitis Laura Webb Lamps, MD Key Facts Terminology Variant of chronic cholecystitis characterized by granulomatous reaction to bile Macroscopic Features Cream to brown tumor-like masses, nodules, or plaques Usually…

Chronic Cholecystitis Kari D. Caradine, MD Key Facts Etiology/Pathogenesis Almost always associated with gallstones Clinical Issues More common in women; approximately 3:1 Microscopic Pathology Predominantly mononuclear inflammatory infiltrate with lymphocytes…

Acute Cholecystitis Vikram Deshpande, MD Key Facts Etiology/Pathogenesis Acute calculous cholecystitis: 95% of cases Acute acalculous cholecystitis: 5% of cases Clinical Issues Right upper quadrant pain, tenderness, and guarding Fever,…

Cholelithiasis Kari D. Caradine, MD Key Facts Terminology Stones in gallbladder or common bile duct Classified by chemical composition into 2 main types: Cholesterol stones and pigment stones Clinical Issues…