Autoimmune Pancreatitis

Autoimmune Pancreatitis

Mari Mino-Kenudson, MD

Hematoxylin & eosin section of lymphoplasmacytic sclerosing pancreatitis shows a prominent fibroinflammatory process with a periductal accentuation image.

The fibroinflammatory process is limited to the periductal region, without significant lobular destruction or interlobular fibrosis, in idiopathic duct-centric chronic pancreatitis.



  • Autoimmune pancreatitis (AIP)


  • Lymphoplasmacytic sclerosing pancreatitis (LPSP)

  • Idiopathic duct-centric chronic pancreatitis (IDCP)

  • Primary sclerosing pancreatitis

  • Nonalcoholic duct destructive chronic pancreatitis


  • Fibroinflammatory disease of presumed autoimmune etiology that affects pancreas

    • Similar fibroinflammatory process often affects other organs such as bile ducts, salivary glands, retroperitoneum, and lymph nodes

    • Associated with many other autoimmune diseases

      • Specific antigenic trigger unknown



  • Jaundice

  • Weight loss

  • Vague abdominal pain

Laboratory Tests

  • Elevated serum IgG4

  • Elevated pancreatic enzymes

  • ANA often positive


  • Surgical approaches

    • Surgically resected when differentiation from pancreatic cancer is difficult or impossible

  • Drugs

    • Steroids


  • Steroid therapy is usually very effective

    • Natural regression seen in some cases

    • Recurrence reported in 6-26%

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Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Autoimmune Pancreatitis

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