Mitochondriopathies Surya V. Seshan, MD Key Facts Etiology/Pathogenesis Rare genetic disorder of mtDNA Drug induced with reverse transcriptase inhibitors Clinical Issues Clinically, biochemically and genetically heterogeneous 50% have renal involvement…
Miscellaneous HIV-associated Renal Diseases A. Brad Farris, III, MD Lupus-like GN is one of the more frequent diseases associated with HIV, typically showing a markedly expanded mesangium , thickened capillary…
Light Chain Fanconi Syndrome Lynn D. Cornell, MD Key Facts Terminology Chronic tubulointerstitial nephropathy caused by intracytoplasmic crystalline inclusions composed of monoclonal light chains present in proximal tubular epithelial cells…
Aristolochic Acid Nephropathy Shane M. Meehan, MBBCh Key Facts Terminology Progressive tubulointerstitial nephropathy and urothelial carcinoma related to aristolochic acid in herbal remedies Etiology/Pathogenesis Patients give history of intake of…
Focal Segmental Glomerulosclerosis, Secondary A. Brad Farris, III, MD Key Facts Terminology FSGS secondary to imbalance of glomerula-functional capacity and demand Etiology/Pathogenesis Adaptive structural-functional response Reduced nephron mass: Oligomeganephronia, reflux…
Type III Hyperlipoproteinemia Helen Liapis, MD Joseph Gaut, MD, PhD Key Facts Etiology/Pathogenesis APOE2 homozygotes Autosomal recessive Clinical Issues Males more commonly affected Nephrotic syndrome Premature vascular disease Palmar and…
Congenital Nephrotic Syndrome of the Finnish Type Helen Liapis, MD Joseph Gaut, MD, PhD Key Facts Terminology Finnish nephropathy (FN) Occurs in neonates up to 3 months of age and…
Parathyroid Gland: Diagnosis and Margins Parathyroid hyperplasia usually involves all 4 glands but can be asymmetric with marked variation in the extent of glandular involvement (pseudoadenomatous variant). Adenomas are usually…
Classification of Tubulointerstitial Diseases Robert B. Colvin, MD Acute interstitial nephritis was originally described in 1898 by William Councilman as a systemic response to certain extrarenal infections (here an untreated…
Gaucher Glomerulopathy A. Brad Farris, III, MD Key Facts Terminology Gaucher cells accumulate in renal parenchyma Etiology/Pathogenesis Glucosylceramide accumulation 2° to ↓ glucosylceramidase activity Clinical Issues Proteinuria, hematuria, nephrotic syndrome…
