Classical Hodgkin Lymphoma Francisco Vega, MD, PhD Key Facts Clinical Issues CHL can involve extranodal tissues Most common: Spleen, lungs, liver, and bone marrow Macroscopic Features Variable patterns of splenic…

Adult T-cell Leukemia/Lymphoma, HTLV-1+ Carlos E. Bueso-Ramos, MD, PhD Roberto N. Miranda, MD Key Facts Terminology Peripheral T-cell leukemia/lymphoma caused by human T-cell lymphotropic virus type 1 (HTLV-1) 4 clinical…

Nodular Lymphocyte Predominant Hodgkin Lymphoma Pei Lin, MD Key Facts Clinical Issues Peak incidence in 4th decade, affects all age groups Patients often present with stage I or II nodal…

Nodular Sclerosis Hodgkin Lymphoma C. Cameron Yin, MD, PhD Key Facts Terminology Nodular sclerosis is type of CHL composed of lacunar-type HRS cells and inflammatory cells forming nodules surrounded by…

Myeloid/Monocytic Sarcoma Carlos E. Bueso-Ramos, MD, PhD Key Facts Clinical Issues Myeloid/monocytic sarcoma (MS) is tumor mass Can develop de novo (27%), concurrently with, or after diagnosis of AML Can…

Extranodal Marginal Zone B-cell Lymphoma (MALT Lymphoma) Pei Lin, MD Key Facts Etiology/Pathogenesis Infectious agents are implicated in pathogenesis of MALT lymphomas at specific sites Helicobacter pylori: Stomach Campylobacter jejuni:…

Blastic Plasmacytoid Dendritic Cell Neoplasm Wesley O. Greaves, MD L. Jeffrey Medeiros, MD Key Facts Clinical Issues Median age: ˜ 65 years Wide age range: 8-96 years Male to female…

Metastatic Kaposi Sarcoma Carlos E. Bueso-Ramos, MD, PhD Key Facts Etiology/Pathogenesis HHV8 infection plays critical role in most cases Interacts with other factors Clinical Issues Multiple presentations of KS Sporadic…

Immunomodulating Agent-associated Lymphoproliferative Disorders Tariq Muzzafar, MBBS Key Facts Etiology/Pathogenesis Risk factors for IA-LPDs Type of immunosuppressive drug Duration of drug therapy Underlying disease type and disease activity Patient genetic…

Sezary Syndrome Sa A. Wang, MD Key Facts Terminology Sézary syndrome (SS) is defined by triad of Pruritic erythroderma High number of Sézary cells in blood (> 1,000/µL ) Lymphadenopathy,…