Giant Cell Tumor of Tendon Sheath David R. Lucas, MD Key Facts Terminology Localized tenosynovial giant cell tumor, localized PVNS, nodular tenosynovitis Etiology/Pathogenesis Balanced translocation involving 1p13 (CSF1 gene) in…
Multinucleate Cell Angiohistiocytoma David Cassarino, MD, PhD Key Facts Terminology Proliferation of vessels and multinucleated stromal cells Etiology/Pathogenesis May be nonneoplastic reactive process Clinical Issues Usually occurs in patients >…
Angiomyofibroblastoma Cyril Fisher, MD, DSc, FRCPath Key Facts Terminology Benign stromal tumor composed of numerous capillaries and myofibroblasts Clinical Issues Women of reproductive age Arises in vulva or vagina Often…
Digital Fibromatosis (Infantile Digital Fibromatosis) Elizabeth A. Montgomery, MD Key Facts Terminology Benign proliferation of fibroblasts and myofibroblasts containing scattered eosinophilic inclusion bodies that occur on digits of young children…
Fibrous Hamartoma of Infancy Elizabeth A. Montgomery, MD Key Facts Terminology Benign superficial fibrous lesion occurring during 1st 2 years of life Clinical Issues Congenital in up to 25% of…
Dermatomyofibroma David Cassarino, MD, PhD Key Facts Terminology Myofibroblastic tumor with features overlapping with dermatofibroma Clinical Issues Slow-growing plaque or nodule Most cases present in shoulder and axillary regions Microscopic…
Dermatofibroma and Fibrous Histiocytoma David Cassarino, MD, PhD Key Facts Terminology Benign, limited proliferation of histiocytic and fibroblastic cells in dermis Etiology/Pathogenesis Evidence supports both neoplastic and reactive pathogenesis Clinical…
Epithelioid Cell Histiocytoma David Cassarino, MD, PhD Key Facts Terminology Dermal-based benign fibrohistiocytic tumor, which can mimic melanocytic, vascular, epithelial, or other histiocytic lesions Clinical Issues Usually occur in young…
Acral Fibrokeratoma Steven D. Billings, MD Key Facts Microscopic Pathology Dome-shaped to elongated silhouette Epidermis is hyperkeratotic and acanthotic Relatively hypocellular proliferation of fibroblasts Vertically oriented thick collagen bundles Top…
Angiofibroma and Related Lesions Steven D. Billings, MD Key Facts Clinical Issues Fibrous papule Adenoma sebaceum: Angiofibromas associated with tuberous sclerosis Solitary dome-shaped flesh-colored papules on nose or central face…
