Extramedullary Hematopoiesis Aaron Auerbach, MD, PhD Key Facts Terminology Formation of blood cells (erythroid cells, myeloid cells, megakaryocytes) outside bone marrow Most common in liver and spleen Hematopoiesis occurs in…
Systemic B-cell Lymphomas Involving the Skin Aaron Auerbach, MD, PhD Key Facts Terminology B-cell lymphoma that has spread to skin as a secondary site of disease Clinical Issues Systemic B-cell…
Lymphomatoid Granulomatosis Aaron Auerbach, MD, PhD Key Facts Terminology Extranodal angiocentric mature B-cell lymphoma that expresses Epstein-Barr virus (EBV) antigens Etiology/Pathogenesis Associated with immunodeficiency, ↑ involvement with allogeneic organ transplant,…
Cutaneous Marginal Zone B-cell Lymphoma Aaron Auerbach, MD, PhD Key Facts Terminology Non-Hodgkin small B-cell lymphoma of centrocytelike marginal zone cells Malignant B cells expanding marginal zones surrounding reactive follicles…
Adult T-cell Leukemia/Lymphoma Aaron Auerbach, MD, PhD Key Facts Etiology/Pathogenesis Long latency period between HTLV-1 infection and tumor development Small risk of ATLL in HTLV-1 infected people Tax viral oncoprotein…
Primary Cutaneous Follicle Center Lymphoma Aaron Auerbach, MD, PhD Key Facts Terminology PCFCL Mature B-cell lymphoma of follicle center cells, primary to skin and not originating in another anatomic site…
Diffuse Large B-cell Lymphoma, Leg Type Sa A. Wang, MD Key Facts Terminology Primary cutaneous DLBCL composed exclusively of large transformed cells Clinical Issues 20% of primary cutaneous B-cell lymphomas…
Intravascular Large B-cell Lymphoma Francisco Vega, MD, PhD Key Facts Terminology Rare large B-cell lymphoma characterized by selective intravascular growth Clinical Issues Heterogeneous clinical signs: Nodules/plaques (49%), macules (23%), telangiectatic…
Histiocytic Sarcoma Aaron Auerbach, MD, PhD Key Facts Terminology Histiocytic sarcoma (HS) Malignant histiocytosis Extramedullary monocytic tumor Clinical Issues Extremely rare tumor Mostly seen in adults Usually rash or single…
Non-Langerhans Cell Histiocytoses Aaron Auerbach, MD, PhD Key Facts Terminology Wide range of histiocytic disorders that are not derived from Langerhans cells Sometimes difficult to categorize because of overlapping morphologic…
