Pigmented Epithelioid Melanocytoma (“Animal-type Melanoma”) Soheil Sam Dadras, MD, PhD Olubukola Babalola Key Facts Clinical Issues Heavily pigmented, dome-shaped nodule Occur sporadically or in association with Carney complex Low-grade malignant…
Molecular Factors Index Molecular Factors Discussed Molecular Factor Chromosomal Location Definition/Alternative Names Chapters β-catenin (see CTNNB1) 10p, loss of 10p Childhood Melanoma 10q, loss of 10q Childhood Melanoma; Perineurioma 11p,…
Melanoma, Superficial Spreading Type Soheil Sam Dadras, MD, PhD Nicole Carreau Key Facts Terminology Most common variant of invasive melanoma Clinical Issues Most frequently occurs on back for males, legs…
Antibody Index Antibodies Discussed Antibody Name/Symbol Antibody Description Clones/Alternative Names Chapters α1-antichymotrypsin alpha 1 antichromotrypsin A1ACT Myofibroma and Myofibromatosis; PEComas α-fetoprotein alpha 1 fetoprotein AFP, Z5A06, Clone C3 Metastatic Tumors…
Oral Melanoma Lester D. R. Thompson, MD Key Facts Terminology Malignant neural crest-derived neoplasm with melanocytic differentiation Clinical Issues Extremely rare, accounting for < 1% of all melanomas Represent <…
Primary Dermal Melanoma David Cassarino, MD, PhD Key Facts Terminology Primary cutaneous melanoma arising in dermis or subcutis, mimicking metastatic melanoma By definition, lacks any evidence of epidermal involvement, ulceration,…
Malignant Cellular Blue Nevus (Melanoma Arising in Cellular Blue Nevus) David Cassarino, MD, PhD Key Facts Terminology Malignant dermal-based melanocytic neoplasm with associated cellular blue nevus or features simulating cellular…
Childhood Melanoma Jeremy C. Wallentine, MD Brian Hall, MD Key Facts Clinical Issues Knowledge of clinical dimensions is of maximum importance Ensure viewing of entire lesion before making a benign…
Acral Lentiginous Melanoma Soheil Sam Dadras, MD, PhD Nicole Carreau Key Facts Terminology Acral melanoma that grows in a lentiginous pattern Clinical Issues < 5% of all malignant melanomas Most…
Mucosal Melanoma (Genital) Elsa F. Velazquez, MD Key Facts Clinical Issues Vulva (most frequent site in females) Glans penis (most common site in males) Flat to nodular to polypoid lesions…
