Mucosal Melanoma (Genital)



Mucosal Melanoma (Genital)


Elsa F. Velazquez, MD










Clinical photograph shows a mucosal melanoma on the glans penis of an elderly patient. Histologic examination showed an invasive nodular type melanoma.






Mucosal melanoma in situ of the vulva shows a lentiginous and confluent pattern of growth without significant pagetoid spread (similar to lentigo maligna) image.


TERMINOLOGY


Abbreviations



  • Mucosal malignant melanoma (MMM)


Synonyms



  • Vulvar melanoma, vaginal melanoma, penile melanoma, scrotal melanoma


Definitions



  • Malignant tumor of melanocytes


ETIOLOGY/PATHOGENESIS


Unknown in Most Cases



  • Alterations in KIT (~ 30% of cases)


  • NRAS mutations have been reported


  • 6% are associated with nevi


  • Family history and genetic susceptibility


CLINICAL ISSUES


Epidemiology



  • Incidence



    • Rare



      • ˜ 2% of all melanomas in females


      • Even less frequent in males


  • Age



    • 6th to 7th decade

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Mucosal Melanoma (Genital)
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