Darier Disease Irina Margaritescu, MD, DipRCPath Key Facts Terminology Autosomal dominant genodermatosis characterized by greasy hyperkeratotic papules in seborrheic regions, nail abnormalities, and mucous membrane changes Etiology/Pathogenesis Mutations in gene…
Acute Generalized Exanthematous Pustulosis Gretchen Frieling, MD David J. DiCaudo, MD Martin C. Mihm, Jr., MD Key Facts Terminology Sudden onset of numerous, small, nonfollicular pustules superimposed on a pruritic,…
Lupus Erythematosus and Variants Julie E. Jackson, MD Chandra N. Smart, MD Key Facts Terminology Multisystem autoimmune disorder with several variants that can affect skin alone or skin and multiple…
Neutrophilic Eccrine Hidradenitis Cary Chisholm, MD Key Facts Etiology/Pathogenesis Usually associated with induction chemotherapy Has been reported in other patients with malignancies, HIV, Behçet disease, and bacterial infections Clinical Issues…
Fox-Fordyce Disease Michael W. Peterson, DO Cary Chisholm, MD Clay J. Cockerell, MD Key Facts Clinical Issues Age 13-35 years old Gender 90% female Apocrine distribution Primarily axilla, periareolar, and…
Annular Elastolytic Giant Cell Granuloma Cary Chisholm, MD Key Facts Terminology Granulomatous infiltrate with phagocytosis and destruction of elastic fibers Clinical Issues Erythematous papules and plaques, which are often annular…
Amyloidosis Kajsa Affolter, MD Key Facts Clinical Issues SA: Non-pruritic, waxy papules on scalp, neck, and, face with predilection for periorbital area and plaque-like lesions on hands and flexural areas…
Foreign Body Granuloma Brian J. Hall, MD John C. Hall, MD Key Facts Terminology Granulomatous inflammation as a response to traumatically introduced substances Clinical Issues Firm, usually colorless nodule that…
Granuloma Annulare Christine J. Ko, MD Key Facts Clinical Issues Most commonly localized over backs of hands/feet or on arms/legs Pink-red to slightly brown or purple 1-2 mm papules in…
Juvenile Xanthogranuloma Christine J. Ko, MD Key Facts Microscopic Pathology Dermal nodule of mixed inflammation Predominantly histiocytes Varying morphologies: Vacuolated, xanthomatized, scalloped, oncocytic, spindle-shaped Admixed lymphocytes, eosinophils, occasional neutrophils and…
