Miscellaneous Xanthomas Jonathan B. McHugh, MD Key Facts Terminology Mass-forming collection of lipidized macrophages Reactive process usually resulting from altered serum lipid levels Etiology/Pathogenesis Associated with hereditary lipoproteinemias and occasionally…
Multinucleate Cell Angiohistiocytoma David S. Cassarino, MD, PhD Key Facts Terminology Proliferation of vessels and multinucleated stromal cells Etiology/Pathogenesis May be nonneoplastic reactive process Clinical Issues Usually occur in patients…
Cellular Neurothekeoma Cyril Fisher, MD, DSc, FRCPath Key Facts Terminology Multinodular dermal tumor composed of nests of rounded cells separated by delicate fibrous septa Differs from dermal nerve sheath myxoma…
Plexiform Xanthoma Jonathan B. McHugh, MD Key Facts Clinical Issues Rare Tend to occur in young adults (4th decade) Most often occur in extremities Elbow and knee regions most frequent…
Reticulohistiocytoma David S. Cassarino, MD, PhD Key Facts Terminology Proliferation of histiocytes with abundant dense, glassy-appearing eosinophilic cytoplasm Clinical Issues Usually occurs in adults > 40 years old, but cases…
Multicentric Reticulohistiocytosis David S. Cassarino, MD, PhD Key Facts Terminology Giant cell reticulohistiocytosis Clinical Issues Most cases occur in adults > 40 years old Multiple nodules and arthropathy Prognosis is…
Giant Cell Tumor of Tendon Sheath David R. Lucas, MD Key Facts Terminology Localized tenosynovial giant cell tumor, localized pigmented villonodular synovitis (PVNS), nodular tenosynovitis Benign soft tissue tumor of…
Juvenile Xanthogranuloma Elizabeth A. Montgomery, MD Key Facts Terminology Stable or regressing histiocytic lesion that usually occurs in childhood Form of non-Langerhans histiocytosis Clinical Issues Majority in individuals under 3…
Dermatofibroma (Benign Fibrous Histiocytoma) David S. Cassarino, MD, PhD Key Facts Terminology Benign limited proliferation of histiocytic and fibroblastic cells in dermis Etiology/Pathogenesis Evidence supports both neoplastic and reactive pathogenesis…
Deep Benign Fibrous Histiocytoma Elizabeth A. Montgomery, MD Key Facts Clinical Issues Painless mass of subcutaneous tissue Most common location is lower extremity Local recurrences common (about 20%) Rare metastases…
