Multicentric Reticulohistiocytosis



Multicentric Reticulohistiocytosis


David S. Cassarino, MD, PhD









Low-power examination shows a dermal-based proliferation containing numerous enlarged histiocytic-appearing cells associated with a background mixed inflammatory infiltrate.






Higher magnification shows a population of enlarged histiocytic cells with abundant dense eosinophilic cytoplasm and 1 to several oval to reniform nuclei.


TERMINOLOGY


Abbreviations



  • Multicentric reticulohistiocytosis (MCR)


Synonyms



  • Giant cell reticulohistiocytosis


  • Reticulohistiocytosis of skin and synovia


Definitions



  • Proliferation of large histiocytes with dense eosinophilic cytoplasm involving multiple organs


ETIOLOGY/PATHOGENESIS


Associated Conditions



  • Association with autoimmune disorders and internal malignancies

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Multicentric Reticulohistiocytosis
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