Multicentric Reticulohistiocytosis

Multicentric Reticulohistiocytosis

David S. Cassarino, MD, PhD

Low-power examination shows a dermal-based proliferation containing numerous enlarged histiocytic-appearing cells associated with a background mixed inflammatory infiltrate.

Higher magnification shows a population of enlarged histiocytic cells with abundant dense eosinophilic cytoplasm and 1 to several oval to reniform nuclei.



  • Multicentric reticulohistiocytosis (MCR)


  • Giant cell reticulohistiocytosis

  • Reticulohistiocytosis of skin and synovia


  • Proliferation of large histiocytes with dense eosinophilic cytoplasm involving multiple organs


Associated Conditions

  • Association with autoimmune disorders and internal malignancies

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Multicentric Reticulohistiocytosis

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