Synovial Sarcoma Key Facts Clinical Issues Predilection for young adults (median: 35 years) Female predilection (2:1) Aggressive behavior similar to soft tissue counterpart Microscopic Pathology Uniform and monotonous proliferation of…
Liposarcoma Key Facts Clinical Issues Rare tumor Broad age range; from children to adults (mean age: 43 years) Anterior and posterior mediastinum Dyspnea Chest pain Recurrences in 33% of cases…
Solitary Fibrous Tumor/Fibrosarcoma Key Facts Clinical Issues Most common mesenchymal spindle cell tumor of anterior mediastinum Cough Chest pain Dyspnea Hypoglycemia May be discovered incidentally on routine imaging studies Majority…
De Novo Focal Segmental Glomerulosclerosis Anthony Chang, MD Key Facts Etiology/Pathogenesis Hyperfiltration Severe vascular disease Drug-induced Clinical Issues Proteinuria, nephrotic range Chronic allograft dysfunction Microscopic Pathology Focal, segmental glomerulosclerosis or…
Evaluation of Fibrosis in Renal Allograft A. Brad Farris, III, MD Collagen III immunohistochemistry stains fibrous tissue brown. A positive pixel count algorithm is applied to the immunohistochemistry, and a…
Acquired Multilocular Thymic Cyst Key Facts Etiology/Pathogenesis Acquired reactive process resulting from underlying infectious or inflammatory stimulus Clinical Issues Generally cured by complete surgical excision Rare cases can recur when…
Diffuse Large Cell Lymphoma of the Mediastinum Key Facts Clinical Issues Predominantly affects women in 3rd decade of life Presents with rapidly growing, large (> 10 cm in diameter), infiltrative…
Atypical Thymoma Key Facts Terminology WHO type B3, polygonal cell thymoma, well-differentiated thymic carcinoma Moderately differentiated thymic epithelial neoplasm intermediate between thymoma and thymic carcinoma Microscopic Pathology Confluent sheets of…
Ganglioneuroma Key Facts Terminology Ganglioneuroma (GN) Benign tumor of neural origin Clinical Issues Incidence Tumor is more common in young patients Location More common in posterior mediastinum Symptomatology Chest pain…
