Mycosis Fungoides The term primary cutaneous lymphoma refers to a lymphoma initially diagnosed by skin biopsy in patients without evidence of extracutaneous disease. In the recent World Health Organization (WHO)/European…

Mantle Cell Lymphoma Definition Mantle cell lymphoma (MCL) is a clinically aggressive B-cell lymphoma associated with the t(11;14)(q13;q32) and cyclin D1 overexpression in almost all cases (1). Originally, MCL was…

Adult T-Cell Leukemia/Lymphoma Definition Adult T-cell leukemia/lymphoma (ATLL) is a T-cell neoplasm caused by infection by human T-cell lymphotropic virus type 1 (HTLV-1). Four clinical variants are recognized: acute, lymphomatous,…

Diffuse Large B-Cell Lymphoma Definition Non-Hodgkin diffuse lymphoma of large B cells. Synonyms Lymphoma, diffuse, histiocytic (Rappaport) (1); Lymphoma, large-cell, cleaved, noncleaved, and immunoblastic (Lukes-Collins) (2); Lymphoma, centroblastic and immunoblastic…

Burkitt Lymphoma Definition Burkitt lymphoma (BL) is defined in the WHO classification as a highly aggressive lymphoma, often extranodal, composed of monomorphic, medium-sized B cells with basophilic cytoplasm and numerous…

Lymphomas of Salivary Glands Definition Lymphomas of the salivary glands develop in the lymph nodes and lymphoid tissues embedded in the salivary glands. Epidemiology Lymphomas developing primarily in salivary glands…

Mediastinal Large B-Cell Lymphoma Definition Large B-cell lymphoma of thymic origin arising in the anterior mediastinum. Epidemiology Primary mediastinal large-cell lymphomas represent about 6% of all lymphomas in adults (1)…

Composite Lymphoma Definition The meaning and use of the term composite lymphoma has been used inconsistently over the years. The term was coined by Custer in 1954 for a patient…

Follicular Lymphoma Definition Follicular lymphomas (FLs) are composed of cleaved and noncleaved B cells recapitulating the germinal centers of lymphoid follicles and growing in a nodular pattern. Synonyms Nodular lymphosarcoma;…