Hepatic TB seen in ∼ 1% of patients with active TB  More common in HIV(+) patients Etiology/Pathogenesis • Transmission typically by inhalation  Can reach liver by hematogenous spread or direct spread…

 Most common nonepithelial tumor of extrahepatic bile ducts Clinical Issues • Occur most often in young African American women  Mean age: 34.7 years • Most frequent location is common bile duct • Often…

 S. mansoni and S. japonicum most frequently cause hepatosplenic disease Etiology/Pathogenesis • Infection occurs when cercariae (infectious larvae) leave intermediate host snail and penetrate skin of vertebrate host (in contaminated water)…

 Presumably due to failure of embryonic pancreatic ducts to regress, when they are replaced by permanent ones, that leads to their obstruction and cyst formation in utero  May be associated…

 Most common lethal autosomal recessive inherited disorder in Caucasian population • CFTR mutation on chromosome 7  Abnormal chloride transport in apical membrane of epithelial cells Clinical Issues • 1 in 2,000-2,500 live…

 Progenitor neural crest cells  Embryonic celiac ganglion  Endodermally derived epithelial cells originating from ventral primordium of pancreas (hamartomatous proliferation)  Pancreatic tumor composed of ganglion-islet cell complexes Clinical Issues • Uncommon • 3rd-9th…

 Nuclear staining with CAMTA1 immunohistochemistry • Tumors with YAP1-TFE3  Well-formed vascular channels, tumor cells with voluminous eosinophilic cytoplasm  Nuclear staining with TFE3 immunohistochemistry Top Differential Diagnoses • Dense myxoid stroma and intracytoplasmic…

 Cestode (tapeworm) with wide geographic distribution • E. granulosus (cystic form) and E. multilocularis (alveolar form) most commonly infect humans Etiology/Pathogenesis • Humans infected by exposure to contaminated feces of primary or…

 Large areas of fat necrosis along with variable parenchymal necrosis  Saponification  Hemorrhage, vascular thrombosis • Mild acute pancreatitis is most often clinical (rather than morphologic) diagnosis  Spotty peripancreatic or perilobular fat…

 Most often seen in children  Classic syndrome involves combination of resolving viral illness and salicylate therapy Etiology/Pathogenesis • Pathogenesis unknown • Mitochondrial injury is a key feature • Frequent antecedent viral infection • Salicylate…