Evidence of genetic studies favors neoplastic process Likely from bone marrow-derived myeloid dendritic precursors Clinical Issues • Affects infants and children, rarely adults • Unisystem disease most often involves bone followed by…
Typically transmitted vertically, parenterally, or sexually Clinical Issues • 10% of infected patients become chronically infected 400 million people worldwide have chronic HBV • Symptoms include mild flu-like syndrome, nausea, vomiting, jaundice…
Portal vein thrombosis, systemic inflammatory conditions, some neoplasms such as renal cell carcinoma or lymphoma, artifactual sinusoidal dilatation • Other causes of parenchymal necrosis/hemorrhage Acetaminophen toxicity, ischemic liver injury Sinusoidal DilatationIn…
Most common endemic mycosis in United States • Liver involvement is almost always part of disseminated infection Patients often immunocompromised Liver is involved in up to 90% of cases of disseminated…
Clear to pale cytoplasm with sharp cell border Small, round to oval, uniform nuclei Periodic acid-Schiff without diastase has granular cytoplasmic staining • Exuberant rich capillary network immediately adjacent to epithelium…
Amiodarone Methotrexate Antiretroviral drugs Nifedipine Clinical Issues • Symptoms may present after months to years of therapy Patients may be asymptomatic despite liver injury • Due to long half-life of amiodarone, may…
Porphyria cutanea tarda (PCT) and erythropoietic protoporphyria (EP) associated with hepatic pathology • Terms “hepatic” or “erythropoietic” porphyria based on site of heme precursor accumulation Etiology/Pathogenesis • Genetic: Defect in 1 of…
Tumors – Goals of evaluation are to assess margins and stage tumor Medical liver disease – Goal of evaluation is to determine or confirm cause of liver disease &/or liver failure MACROSCOPIC…
Wide spectrum of disease ranging from subclinical to end-stage liver disease ∼ 20-40% of chronic alcoholics who undergo biopsy have histologic evidence of alcoholic liver disease (ALD) Clinical Issues • Very…
Preformed antibodies Donor-specific antibodies (DSA) developed after transplantation Microscopic • Hyperacute antibody-mediated rejection (AMR) Fibrin thrombi in portal and central veins and sinusoids Neutrophilic &/or fibrinoid arteritis Patchy or massive hemorrhagic…
