Molecular Defects     More than 90% of patients clinically classified as having MFS by the “Ghent criteria” have a mutation in the gene for fibrillin-1 (FBN1). Mutations in the same gene are…

Molecular Defects     More than 90% of patients clinically classified as having MFS by the “Ghent criteria” have a mutation in the gene for fibrillin-1 (FBN1). Mutations in the same gene are…

236   Histoplasmosis Chadi A. Hage, L. Joseph Wheat ETIOLOGY Histoplasma capsulatum, a thermal dimorphic fungus, is the etiologic agent of histoplasmosis. In most endemic areas, H. capsulatum var. capsulatum is…

247   Amebiasis and Infection with Free-Living Amebas Rosa M. Andrade, Sharon L. Reed AMEBIASIS DEFINITION Amebiasis is an infection with the intestinal protozoan Entamoeba histolytica. About 90% of infections are…

It is now appreciated that genotypes of T. gondii prevalent in South America may be more virulent than those typically seen in North America or Europe. These genotypes may be…

247   Amebiasis and Infection with Free-Living Amebas Rosa M. Andrade, Sharon L. Reed AMEBIASIS DEFINITION Amebiasis is an infection with the intestinal protozoan Entamoeba histolytica. About 90% of infections are…

It is now appreciated that genotypes of T. gondii prevalent in South America may be more virulent than those typically seen in North America or Europe. These genotypes may be…

PYROGENS The term pyrogen (Greek pyro, “fire”) is used to describe any substance that causes fever. Exogenous pyrogens are derived from outside the patient; most are microbial products, microbial toxins,…

It is now appreciated that genotypes of T. gondii prevalent in South America may be more virulent than those typically seen in North America or Europe. These genotypes may be…

274   The Bradyarrhythmias: Disorders of the Sinoatrial Node David D. Spragg, Gordon F. Tomaselli Electrical activation of the heart normally originates in the sinoatrial (SA) node, the predominant pacemaker. Other…