Carcinomas with Extensive Intraductal Component
 This invasive ductal carcinoma  is present in an area of fibroadipose tissue. There is no DCIS in the surrounding tissue. This carcinoma would be classified as EIC negative. |
 Invasive carcinomas  may be associated with extensive carcinoma in situ, both within the carcinoma  and outside the carcinoma  . This carcinoma would be classified as EIC positive. |
TERMINOLOGY
Abbreviations
Extensive intraductal component (EIC)
Definitions
Classification of extent of DCIS associated with invasive carcinomas
Correlated with multiple foci of invasion and margin involvement
Increases risk of local recurrence in absence of wide local excision
ETIOLOGY/PATHOGENESIS
Histogenesis
Subset (25-40%) of invasive carcinomas are associated with extensive DCIS (an EIC) in adjacent tissue
Risk of local recurrence is diminished if all DCIS is removed surgically
Positive or close margins are predictors of residual DCIS in breast
EIC is not predictive for overall survival or distant metastasis
Multiple foci of invasion may be present
EIC is the most common source of multiple synchronous invasive carcinomas
If EIC is present, 17% of cases have multiple foci of invasion
If EIC is not present, 5% of cases have multiple foci of invasion
Multiple carcinomas are usually similar in histologic appearance and marker studies
Tend to be smaller than cancers without an EIC
Larger group (60-75%) of cancers are associated with little or no recognizable DCIS (EIC negative)
Triple negative cancers are in this group
It is possible that triple negative DCIS rapidly progresses to invasion and may be overgrown by invasive component
LCIS at margins has not been consistently shown to increase likelihood of recurrence
EIC is only used for DCIS
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