Bowenoid Papulosis



Bowenoid Papulosis


Elsa F. Velazquez, MD

Antonio L. Cubilla, MD





Key Facts


Etiology/Pathogenesis



  • Most often related to HPV 16


Clinical Issues



  • Often multifocal


  • Benign-looking papules


  • Usually affecting skin of shaft of young adults


  • May also affect glans and coronal sulcus


Microscopic Pathology



  • Proliferation of atypical basaloid and koilocytic cells as scattered single units or involving full thickness of epithelium


  • Most cases are indistinguishable from SCCIS


Top Differential Diagnoses



  • Squamous cell carcinoma in situ (SCCIS)


  • Treated condyloma







Patchy foci of atypia are present throughout the epidermis. Atypical cells vary from small basaloid to larger and more pleomorphic cells with koilocytic-like changes.






There is full thickness atypia of the squamous epithelium with preserved maturation and koilocytic change.


TERMINOLOGY


Abbreviations



  • Bowenoid papulosis (BP)


Definitions



  • Multifocal HPV-related papular condition affecting anogenital region in young adults


  • Lesions exhibit spectrum of changes from dysplasia to in situ carcinoma; usually associated with favorable prognosis


ETIOLOGY/PATHOGENESIS


Etiology



  • Related to high-risk types of HPV, especially type 16


  • Other types of HPV (18, 31, 32, 33, 34, 35, 39, 42, 48, 51, 52, 53, and 54) have also been implicated


  • Usually transmitted via sexual contact


Pathogenesis



  • Oncogenic HPV elaborate proteins that interfere with normal cellular homeostasis

Tags:
Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Bowenoid Papulosis

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