Calcineurin Inhibitor Toxicity Shane M. Meehan, MBBCh Key Facts Terminology Kidney dysfunction attributable to injury from calcineurin inhibitor immunosuppressive therapy Etiology/Pathogenesis Transplanted and native kidneys affected by CIT CIT is…
Recurrent Primary Biliary Cirrhosis Rish K. Pai, MD, PhD Key Facts Clinical Issues Prevalence increases progressively post transplantation 30-50% recurrence within 10 years Most are found to have recurrent disease…
Chronic (Ductopenic) Rejection Matthew M. Yeh, MD, PhD Key Facts Microscopic Pathology Atypical bile duct epithelium resembling dysplasia Centrizonal perivenular hepatocyte dropout Loss of interlobular bile ducts > 50% of…
Thymic Carcinoma Key Facts Clinical Issues Generally poor prognosis High-grade tumors have median survival of 18 months Usual sites of metastases include lymph nodes, bone, lung, pleura, liver, and brain…
Cryptococcosis Anthony Chang, MD Key Facts Etiology/Pathogenesis Cryptococcus neoformans Cryptococcus gattii Clinical Issues Rare in children before puberty Male predilection Treatment Amphotericin B Fluconazole Microscopic Pathology Granulomatous interstitial inflammation Fungal…
Synovial Sarcoma Key Facts Clinical Issues Predilection for young adults (median: 35 years) Female predilection (2:1) Aggressive behavior similar to soft tissue counterpart Microscopic Pathology Uniform and monotonous proliferation of…
Liposarcoma Key Facts Clinical Issues Rare tumor Broad age range; from children to adults (mean age: 43 years) Anterior and posterior mediastinum Dyspnea Chest pain Recurrences in 33% of cases…
Solitary Fibrous Tumor/Fibrosarcoma Key Facts Clinical Issues Most common mesenchymal spindle cell tumor of anterior mediastinum Cough Chest pain Dyspnea Hypoglycemia May be discovered incidentally on routine imaging studies Majority…
De Novo Focal Segmental Glomerulosclerosis Anthony Chang, MD Key Facts Etiology/Pathogenesis Hyperfiltration Severe vascular disease Drug-induced Clinical Issues Proteinuria, nephrotic range Chronic allograft dysfunction Microscopic Pathology Focal, segmental glomerulosclerosis or…
Evaluation of Fibrosis in Renal Allograft A. Brad Farris, III, MD Collagen III immunohistochemistry stains fibrous tissue brown. A positive pixel count algorithm is applied to the immunohistochemistry, and a…
