Embryology and Developmental Lesions Paul W. Biddinger EMBRYOLOGY Embryologic Origination Knowledge of the embryologic development of the thyroid is key to understanding several abnormalities of the thyroid gland. The gland…
Thyroid Tumors: Classification, Staging, and General Considerations Yuri E. Nikiforov CLASSIFICATION A histologic classification of thyroid tumors is shown in Table 7.1. It incorporates main principles of the current World…
Normal Anatomy and Histology Paul W. Biddinger Descriptions of the thyroid and related diseases date back to antiquity. The thyroid was identified by European anatomists during the Renaissance including Vesalius…
Thyroid Physiology Peter Kopp THYROID HORMONE SYNTHESIS AND SECRETION Thyroid hormones are essential for normal growth and development, particularly of the central nervous system, and they play a key role…
Molecular Factors Index Molecular Factors Discussed Molecular Factor Gene Location Definition/Alternative Names Chapter ALK1 12q13.13 ACVRL1; anaplastic lymphoma receptor tyrosine kinase Pulmonary Arterial Hypertension BCL6 3q27 B-cell CLL/lymphoma 6 Post-Transplant…
Antibody Index Antibodies Discussed Antibody Name/Symbol Antibody Description Clones/Alternative Names Chapters κ light chain kappa light chain KAPPA Evaluation of Transplant Nephrectomy λ light chain lambda light chain LAMBDA Evaluation…
Microaspiration Aliya N. Husain, MD Ilyssa O. Gordon, MD, PhD Key Facts Terminology Microscopic aspiration of gastric contents usually associated with symptoms of GERD Clinical Issues GERD is common in…
Acute Antibody-Mediated Rejection, Kidney Lynn D. Cornell, MD Key Facts Etiology/Pathogenesis DSA usually directed against HLA class I or II on endothelium May be against ABO blood group antigens in…
Cytomegalovirus Nephritis Anthony Chang, MD Key Facts Terminology CMV infection in kidneys, usually associated with systemic CMV in immunocompromised patient Etiology/Pathogenesis Cytomegalovirus Immunocompromised patients at risk Clinical Issues Presentation Renal…
De Novo Membranous Glomerulonephritis Anthony Chang, MD Key Facts Clinical Issues 0.5-9% of kidney transplant patients Proteinuria Renal dysfunction Unfavorable prognosis 2/3 of patients eventually require renal replacement therapy Microscopic…
