Treatment of COVID-19 in Adults Nikolaus Jilg Adil Yunis Christopher Newton-Cheh Rajesh T. Gandhi INTRODUCTION COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in late 2019 and…
Potential Treatments for SARS-CoV-2 Beyond Current and Related New-Generation Antivirals and Monoclonal Antibodies Roberto Patarca William A. Haseltine INTRODUCTION Available vaccines, monoclonal antibodies, and antivirals for severe acute respiratory syndrome…
COVID-19 Testing for Medicine and Public Health Michael J. Mina INTRODUCTION The coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented tragedy and disruptions to society on a global scale. When…
Organ Pathogenesis: Lung, Heart, Kidney, Liver, Pancreas, Brain Nagme Bilgehan Galatea Stavraka Justin Stebbing INTRODUCTION During the early stages of the coronavirus disease 2019 (COVID-19) outbreak in 2020, the general…
T Cells and COVID-19 Shiv Pillai INTRODUCTION: T-CELL RESPONSES TO VIRUSES When one considers immune responses to viruses in general, there is broad acceptance, largely based on studies on rodents…
Pediatric COVID Anna Martens Lael Yonker INTRODUCTION During the early phases of the coronavirus disease 2019 (COVID-19) pandemic, hospitals were inundated with adults infected with severe acute respiratory syndrome coronavirus…
Long COVID Roberto Patarca INTRODUCTION Beyond the human toll of its acute-phase and devastating socioeconomic impact, the still lingering severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 pandemic1,2 that started toward the…
Genetic Determinants of Susceptibility and Resistance to SARS-CoV-2 Maureen P. Martin Mary Carrington INTRODUCTION The clinical manifestations after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vary greatly across…
SARS-CoV-2 Variants Jacob E. Lemieux Jeremy Luban INTRODUCTION Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are clusters of mutations that create distinct genetic lineages of SARS-CoV-2. Several such lineages…
Structure and Function of SARS-CoV-2 Spike Protein Bing Chen Jeremy Luban SARS-COV-2 AND CORONAVIRUS PHYLOGENY The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2…
