Hodgkin Lymphoma: Classical Definition Hodgkin lymphoma (HL) is characterized by a heterogeneous cellularity comprising a minority of specific neoplastic cells—the Hodgkin cells and the Reed-Sternberg cells—and a majority of reactive…
Hodgkin Lymphoma: Nodular Lymphocyte Predominant Definition A monoclonal B-cell neoplasm characterized by a nodular pattern, with or without diffuse areas, in which large neoplastic lymphocytic and/or histiocytic (L&H) cells are…
Nomenclature and Classification of Lymphomas Traditionally, tumors of various organs have been named and classified according to their histogenesis. This concept is based on the assumption that tumors originate in…
Introduction For the hematopathologist involved in scientific research, lymphomas and leukemias present the most challenging field of medical investigation, one in which immunity and neoplasia interface and in which new…
Nevus Cell Inclusions in Lymph Nodes Definition Aggregates of nevus cells in the lymph node hilus, capsule, or trabeculae. Pathogenesis Aggregates of nevus cells within peripheral lymph nodes, first described…
Epithelial Cell Inclusions in Lymph Nodes Definition Clusters of benign, well-differentiated epithelial cells in lymph nodes. Pathogenesis The presence of epithelial cells in lymph nodes is usually the result of…
Gold Lymphadenopathy Definition Lymphadenopathy caused by intramuscular injections of gold and subsequent deposit in lymph nodes. Pathogenesis In chrysotherapy for rheumatoid arthritis, gold sodium thiomalate is injected intramuscularly over long…
Lymphadenopathy of Metal Debris Associated with Joint Prostheses Definition Lymphadenopathy caused by abraded metal debris drained from sites of joint prostheses. Pathogenesis The use of metal prostheses to replace large…
Silicone Lymphadenopathy Definition Lymphadenopathy of regional lymph nodes caused by the presence of silicone carried from tributary organs. Pathogenesis Silicone consists of polymers of dimethylsiloxane. When repeating units are polymerized,…
Lipid Lymphadenopathy Definition Lymphadenopathy with foreign-body reaction to lipids of endogenous or exogenous origins. Pathogenesis Foreign-body reactions to lipids, in the form of lipogranulomas or lipogranulomatosis, may involve lymph nodes…
