Mediastinal Large B-Cell Lymphoma Definition Large B-cell lymphoma of thymic origin arising in the anterior mediastinum. Epidemiology Primary mediastinal large-cell lymphomas represent about 6% of all lymphomas in adults (1)…
Composite Lymphoma Definition The meaning and use of the term composite lymphoma has been used inconsistently over the years. The term was coined by Custer in 1954 for a patient…
Introduction With the advent of the application of immunophenotyping and molecular analysis to the study of lymphomas, neoplasms arising from T- and NK-cells was recognized and our understanding of these…
Follicular Lymphoma Definition Follicular lymphomas (FLs) are composed of cleaved and noncleaved B cells recapitulating the germinal centers of lymphoid follicles and growing in a nodular pattern. Synonyms Nodular lymphosarcoma;…
Diffuse Follicle Center Cell Lymphoma Definition Diffuse follicle center lymphomas (FCL) are diffusely growing, germinal center–derived lymphomas containing predominantly small cleaved B cells or a mix of small cleaved and…
Lymphoplasmacytic Lymphoma Definition At this time, the definition of lymphoplasmacytic lymphoma (LPL) is in flux. In the World Health Organization (WHO) classification, LPL is defined primarily in the context of…
Hairy Cell Leukemia Definition A chronic lymphoproliferative disorder of mature B cells with characteristic cytoplasmic projections. The neoplasm typically infiltrates the bone marrow, spleen, and liver with relatively few hairy…
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Definition Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are considered to represent different manifestations of the same disease in the World Health Organization…
Nodal Marginal Zone B-Cell Lymphoma Definition Nodal marginal zone B-cell lymphoma (MZL) is a clinically indolent neoplasm that involves lymph nodes. As defined in the World Health Organization (WHO) classification,…
Lymphoblastic Leukemia/Lymphoma In the World Health Organization (WHO) classification, the commonly used acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) are combined into the term lymphoblastic leukemia/lymphoma. This reflects the…
