Figure 8.1The parameters studied for optimization of the formulation and process variables (18) and a representative response surface* (Q10 = percent dissolved in 10 min). (Courtesy of L. Augsburger.) *Response…
Chapter 10 TRPA1 Antagonists as Potential Therapeutics for Respiratory Diseases Jessica Tan1,2; Gerald Hunsberger2; Christopher Neipp3; M. Allen McAlexander2,* 1 Department of Biology, College of Science and Technology, Temple University, Philadelphia,…
Chapter 24 Mucolipidosis Type IV Part I Ehud Goldin* SENS Research Foundation, Mountain View, CA, USA* Corresponding author: ehud.goldin@sens.org Abstract Mucolipidosis IV is a neurodevelopmental disorder caused by mutations in the…
Chapter 13 Potential Therapeutic Applications for TRPV4 Antagonists in Lung Disease Mary I. Townsley*; James C. Parker Department of Physiology and Center for Lung Biology, University of South Alabama, Mobile, Alabama,…
Chapter 12 Small Molecule Agonists and Antagonists of TRPV4 Matthew A.J. Duncton* Renovis, Inc. (a wholly owned subsidiary of Evotec AG), South San Francisco, California, USA* Corresponding author: mattduncton@yahoo.com Abstract Transient…
Chapter 14 TRPM8 as a Target for Analgesia Rory Mitchell1,*; Susan Fleetwood-Walker1,* 1 Centre for Integrative Physiology, School of Biomedical Sciences, College of Medicine & Veterinary Medicine, University of Edinburgh, Scotland,…
Chapter 6 TRPV1 Agonist Cytotoxicity for Chronic Pain Relief From Mechanistic Understanding to Clinical Application Dorothy Cimino Brown1,2,*; Michael J. Iadarola3 1 Veterinary Clinical Investigations Center, School of Veterinary Medicine, University…
Chapter 4 TRP Gene Polymorphism and Disease Risk Ina Kraus-Stojanowic1; Ralf Baron2; Ingolf Cascorbi1,* 1 Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Kiel, Germany2 Division of Neurological Pain Research…
Chapter 16 Activating, Inhibiting, and Highjacking TRP Channels for Relief from Itch Lindsey M. Snyder1,3,4; Huizhen Huang1,3,5; Sarah E. Ross1,2,3,4,* 1 Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA2 Department…
Chapter 8 Clinical and Preclinical Experience with TRPV1 Antagonists as Potential Analgesic Agents Arthur Gomtsyan1,*; Jill-Desiree Brederson2 1 Department of Chemistry, Research and Development, AbbVie Inc., North Chicago, Illinois, USA2 Global…
