CHAPTER 9 Abnormalities of the structure and synthesis of hemoglobin SL. Thein Chapter contents INTRODUCTION 131 NORMAL HUMAN HEMOGLOBIN: STRUCTURE AND SYNTHESIS 131 INHERITED DISORDERS OF HEMOGLOBIN 133 THALASSEMIAS 134…
CHAPTER 10 Acquired hemolytic anemia DM. Arnold, I. Nazi, JC. Moore, NM. Heddle, JG. Kelton Chapter contents INTRODUCTION 157 CLINICAL AND LABORATORY FEATURES OF HEMOLYTIC ANEMIA 157 MECHANISMS OF HEMOLYSIS…
CHAPTER 16 Abnormalities in leukocyte morphology and number G. Zini Chapter contents NEUTROPHILS 247 Neutropenia 247 Congenital and idiopathic neutropenias 248 Acquired neutropenias 250 Infections associated with neutropenia 250 Drug-induced…
CHAPTER 14 Sideroblastic anemia A. May Chapter contents HEREDITARY SIDEROBLASTIC ANEMIA 225 X-linked inheritance 225 ALA synthase 2 defect 225 ABCB7 defect 228 Autosomal recessive sideroblastic anemia 228 Putative deficit…
CHAPTER 36 Natural anticoagulants and thrombophilia E. Norström, G. Escolar Chapter contents INTRODUCTION 583 COAGULATION 584 Classic cascade mechanism of coagulation vs. cell-based models of thrombin generation 584 Molecular mechanism…
CHAPTER 21 Molecular studies in myeloproliferative and myelodysplastic/myeloproliferative neoplasms O. Bock, HH. Kreipe Chapter contents INTRODUCTION 321 THE PHILADELPHIA CHROMOSOME AND BCR-ABL IN CHRONIC MYELOGENOUS LEUKEMIA 322 THE JANUS KINASE…
CHAPTER 13 Aplastic anemia and pure red cell aplasia EC. Gordon-Smith Chapter contents ACQUIRED APLASTIC ANEMIA 213 Definition and differential diagnosis 213 Etiology 214 Drugs 214 Industrial/domestic chemicals 214 Viruses…
CHAPTER 35 Acquired bleeding disorders DJ. Perry, C. Grove Chapter contents INTRODUCTION 566 PHYSIOLOGICAL DEFICIENCIES 566 Neonates 566 DRUG-INDUCED BLEEDING DISORDERS 566 Heparin 566 Laboratory monitoring 566 Hirudin and bivalirudin…
CHAPTER 38 Transfusion medicine for pathologists J. McCullough Chapter contents INTRODUCTION 620 BLOOD SUPPLY SYSTEMS THROUGHOUT THE WORLD 620 Whole blood 620 Blood donor recruitment 620 Plasma 621 WHOLE BLOOD…
CHAPTER 6 Investigation and classification of anemia WN. Erber Chapter contents DEFINITION AND CAUSES OF ANEMIA 105 CLINICAL FEATURES OF ANEMIA 105 THE BLOOD COUNT AND RED CELL INDICES IN…
