Peripheral neuropathic conditions treated with Topical capsaicin Postherpetic neuralgia (PHN) Painful diabetic polyneuropathy (PDPN) HIV-associated distal symmetrical polyneuropathy (HIV-DSPN) Persistent postsurgical pain 4.2 Neuropathic Pain Whether noted by clinician or…
Route Treatment Proposed mechanism of action Observation Spontaneous voiding – Oral Antimuscarinics Suppresses detrusor muscle contractions Tricyclic antidepressant Central and peripheral anticholinergic Catheterization Intermittent Drainage of bladder/urinary tract Condom (male)…
Dermatologic condition Clinical manifestations Post-herpetic neuralgia Pain persisting more than 90 days following the occurrence of herpes zoster infection Notalgia paresthetica Focal pruritus typically located unilaterally on the mid- or upper…
Omar M. E. Abdel-Salam (ed.)Progress in Drug ResearchCapsaicin as a Therapeutic Molecule201410.1007/978-3-0348-0828-6_7 © Springer Basel 2014 7. Capsaicin as an Anti-Obesity Drug Felix W. Leung1, 2, 3 (1) 111G, Division of Gastroenterology, Sepulveda Ambulatory Care Center,…
Fig. 2.1 Critical residues involved in TRPV1 function. TRPV1 topology highlighting residues implicated in the activation, sensitisation, desensitisation, gating properties or permeation of the channel 2.6.1 The N Terminus Like other…
Fig. 6.1 Outlines the hypothetical mechanisms of AR, NAR, or MR and the role of capsaicin in TRPV1 desensitization in such clinical conditions. Stimulation of maxillary division of trigeminal nerves (V2)…
Fig. 5.1 Potential for TRPV1 modulation to reduce pain related to opioid-induced hyperalgesia. Either capsaicin-based defunctionalization or outright TRPV1 antagonism may be useful in alleviating this subset of chronic pain Further…
Chapter 14 Amino Acid Metabolism Margaret E. Brosnan, PhD and John T. Brosnan, DPhil, DSc∗ This discussion of amino acid metabolism focuses on the metabolism of the 20 α-amino (or…
Chapter 16 Metabolism of Fatty Acids, Acylglycerols, and Sphingolipids Hei Sook Sul, PhD Common Abbreviations ACP acyl carrier protein AMPK 5′-AMP–activated protein kinase cAMP 3′-5′-cyclic adenosine monophosphate CoA coenzyme A…
Chapter 12 Carbohydrate Metabolism Synthesis and Oxidation Mary M. McGrane, PhD Common Abbreviations AMPK adenosine monophosphate (AMP)-activated protein kinase ChREBP carbohydrate response element binding protein CoA coenzyme A F2,6P2 fructose…
