Plasmonic Nanobubbles for Cancer Theranostics
Fig. 32.1 Plasmonic bubble generation and detection: a cluster of gold nanoparticles in target cell, b laser pulse (green) nucleates the vapor bubble, c bubble expands and scatters a probe laser…
Cell-based Microfluidic Assays in Translational Medicine
Fig. 33.1 A famous example of neutrophil chemotaxis and phagocytosis. The neutrophil is seen migrating toward a bacterium as it secretes some kind of unknown chemoattractant (e.g., N-formyl peptides like fMLP)….
Photoacoustic Imaging: Development of Imaging Systems and Molecular Agents
, here D T is the thermal diffusivity of the tissue (a constant with a typical value for most tissues of ~1.4 × 10−3 cm2/s) and t p is the laser pulse duration….
Engineering of Photomanipulatable Hydrogels for Translational Medicine
Fig. 34.1 Structure of photopolymerizable macromolecular precursors: a PEG acrylate derivatives, b polyvinyl alcohol (PVA) derivatives, c dextran methacrylate, and d hyaluronic acid derivatives 34.2.2 Photoclick Reactions for Fast Crosslinking or…
Engineering Miniature Imaging Instruments
Spiral Rotational Galvo MEMS Scanner Location Distal Distal Proximal Distal Fast axis >1 kHz >1 kHz 1–5 kHz >3 kHz Slow axis NA NA <10 Hz <30 Hz Footprint <3 mm <3 mm <1 cm <1 mm Fiber (mode)…
Engineering Aptamers for Biomedical Applications: Part I
Fig. 15.1 The general procedure for systematic evolution of ligands by exponential enrichment (SELEX). Recreated with kind permission of Elsevier Ltd [100] 15.2.2 Improved SELEX Along with the continuous development, a…
Opportunities for New Photodynamic Molecular Beacon Designs
Fig. 27.1 a Molecular structure of a pyrene-functionalized cationic oligopeptide. b Binding of the beacon to double-stranded DNA. c Schematic working mechanism (Recreated with kind permission from American Chemical Society; J….
Engineering of Mesoporous Silica Nanoparticles for In Vivo Cancer Imaging and Therapy
Fig. 23.1 a Fluorescence imaging of MSN-NH2-FITC (left) and MSN-ICG (middle) in anesthetized rats before and 90 min after i.v. injection. Scanning time was all set to be 30 s. The fluorescence image…
Engineering AApeptides for Translational Medicine
Fig. 35.1 Examples of unnatural peptidomimetics As they are not based on regular peptide backbones, they are often much more stable against proteolysis and have improved bioavailability compared to peptide counterparts…
Engineering Small Animal Conformal Radiotherapy Systems
Fig. 31.1 State-of-the-art medical linear accelerator (a) and a patient dose distribution generated by a treatment technique called RapidArc (b). Small animal conformal radiotherapy system at Stanford University based on a…
