Therapeutic Potential of Amnion Epithelial Cells for Diabetes
Fig. 23.1 Upper panel: expression of markers in HAE cells and HAM cells. Lane 1: HAE cells, lane 2: pancreatic induced HAE cells, lane 3: HAM cells, lane 4: pancreatic…
The Potential of Human Amnion Epithelial Cells as an Immunomodulatory and Neuroregenerative Treatment for Multiple Sclerosis
Fig. 21.1 CD4+ T-cell differentiation, cytokine production and their implications in EAE and MS. Naïve CD4+ T cells exit the thymus and upon interactions with antigen-presenting cells they differentiate into…
Potential Efficacy of Amnion Epithelial Cells to Treat Post-stroke Inflammation
Fig. 20.1 Schematic diagram of immune cells involved in post-stroke inflammation in the brain. Immune cells infiltrate the ischemic hemisphere and are thought to promote cell injury and death via…
Stimulation of Therapeutic Angiogenesis Using Amniotic Fluid Stem Cells
Fig. 12.1 Proposed model for AFSC-mediated tissue repair. Implanted undifferentiated AFSCs evoke a strong pro-inflammatory and pro-angiogenic response, which accounts for the rapid vascularization of the implantation site. Circulating progenitors…
Towards Clinical Applications of Umbilical Cord Derived Mesenchymal Stem Cells
© Springer Science+Business Media New York 2014Anthony Atala and Sean V. Murphy (eds.)Perinatal Stem Cells10.1007/978-1-4939-1118-9_31 31. Towards Clinical Applications of Umbilical Cord Derived Mesenchymal Stem Cells Rouzbeh R. Taghizadeh1 , Paul W. Holzer2, Teresa Marino3, Kyle J. Cetrulo1 , Curtis L. CetruloSr.4 and Curtis L. CetruloJr.5 (1) AuxoCell…
Umbilical Cord Blood Cells in the Repair of Central Nervous System Diseases
Disease NCT ID Source Dose (/kg) Route Age Follow-up Type of study Location Cerebral Palsy 01072370 Autologous (MNC) 1 × 107 iv 2–12 years old 1 year Phase I/II (placebo, double blinded)…
Collection, Processing, and Banking of Umbilical Cord Blood
Indication Phase Institution Enrollment Clinical trials indicator Autism Phase II Sutter Health 30 NCT01638819 Cerebral palsy Phase I/II Georgia Health Sciences University 40 NCT01072370 Cerebral palsy Phase II Duke University…
Amnion Epithelial Cells for Lung Diseases
Fig. 19.1 Human amnion epithelial cells (hAECs) promote tissue repair via the modulation of host immune cells. Through the secretion of lipoxins and other mediators, hAECs polarize M1 macrophages to…
Placental Stem/Progenitor Cells: Isolation and Characterization
Fig. 13.1 Placenta structure and placenta-derived cells. (a) Illustration of the structure of placenta. (b) Mechanical separation of the fetal membrane and depiction of the different layers of amnion and…
Amniotic Fluid Stem Cells for the Treatment of Articular Cartilage Defects
Developmental stage Genes Extracellular matrix proteins References Interzone formation GDF5 (TGFß-superfamily), Sox9, WNT9a, TGFß, BMP2, BMP4, BMP7 Versican, Collagen I, fibronectin [23, 37, 111–114] Cavitation Sox5, Sox6, Sox9, CD44, BMP2,…
