Cytoplasm: Autophagy
and Jürgen Roth2 (1) Medical University of Vienna, Vienna, Austria (2) University of Zurich, Zurich, Switzerland Autophagy: Limited Self-Digestion Macroautophagy, named autophagy, is a basic process that operates under physiological…
Cytoplasm: Mitochondria and Structural Abnormalities
and Jürgen Roth2 (1) Medical University of Vienna, Vienna, Austria (2) University of Zurich, Zurich, Switzerland Mitochondria: Crista and Tubulus Types, Mitochondrial Networks, and Fission Although known since the early…
Contact Sites
and Jürgen Roth2 (1) Medical University of Vienna, Vienna, Austria (2) University of Zurich, Zurich, Switzerland Contact Sites of Rough Endoplasmic Reticulum with Mitochondria, the Plasma Membrane, and Lipid Droplets…
Morphologic Evaluation
(1) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Morphologic evaluation can be approached by recognizing lineage-specific features and formulating a differential diagnosis…
Immunoperoxidase Studies
Fig. 4.1 Immunostaining using direct smear when cell block is not available (example 1): smears of a squamous carcinoma do not show typical diagnostic features; the diagnosis was confirmed by…
Introduction
(1) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Fine-needle aspiration (FNA) is a safe, simple, rapid, and cost-effective procedure that allows the…
Sample Collection, Preparation, Rapid On-Site Evaluation, and Triage
(1) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Sample Collection and Preparation The success of an FNA procedure depends on the nature…
Flow Cytometric Immunophenotyping
Fig. 5.1 Multicolor flow cytometric immunophenotyping on fine-needle aspiration sample (example 1): the histogram shows coexpression of CD19 and CD5, an important feature of mantle cell lymphoma Fig. 5.2 Multicolor…
Cytogenetic Studies
Tumor type Cytogenetic change Fusion protein Alveolar soft part sarcoma t(X;17)(p11;q25) ASPL–TFE3 Clear cell sarcoma/melanoma of soft parts t(12;22)(q13;q12) EWS–ATF1 t(2;22)(q34;q12) EWS–CREB1 Chondrosarcoma, extraskeletal myxoid t(9;22)(q22:q12) EWS–CHN t(9;17)(q22:q11) RBP56–CHN t(9;15)(q22;q21)…
