Amyloid deposits are congophilic and show “apple green” birefringence under polarized light
Top Differential Diagnoses

Deposits are seen in the hepatic arteriole



Congo red stain highlights the vascular distribution of amyloid deposits in the hepatic arteriole



Congo red stain highlights the diffuse sinusoidal pattern


TERMINOLOGY
Definitions
• Heterogeneous disease characterized by deposition of glycoprotein fibrils in extracellular matrix and vessel walls
• Liver involvement may be seen in different types
Primary, or AL, amyloidosis


– Occurs alone or associated with other hematologic diseases (plasmacytoma, multiple myeloma Waldenstrom macroglobulinemia)

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