Amyloid deposits are congophilic and show “apple green” birefringence under polarized light
Top Differential Diagnoses
Deposits are seen in the hepatic arteriole
and portal vein 
in the vascular pattern of hepatic amyloidosis. This distribution is characteristic, but not specific, for the AA form.
Congo red stain highlights the vascular distribution of amyloid deposits in the hepatic arteriole
and portal vein 
.
Congo red stain highlights the diffuse sinusoidal pattern
of hepatic amyloidosis. The amyloid deposits are compressing the hepatocytes 
, leading to hepatic plate atrophy.
stain with trichrome stain, but it is often a paler staining than that seen with collagen 
.TERMINOLOGY
Definitions
• Heterogeneous disease characterized by deposition of glycoprotein fibrils in extracellular matrix and vessel walls
• Liver involvement may be seen in different types
Primary, or AL, amyloidosis
Primary, or AL, amyloidosis– Occurs alone or associated with other hematologic diseases (plasmacytoma, multiple myeloma Waldenstrom macroglobulinemia)
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