Undifferentiated Carcinoma
Wide range of morphologic findings ranging from pleomorphic epithelioid cells to multinucleated giant cells to spindle cells Clinical Issues • Rare • Prognosis is dismal, often < 1 year • Surgical resection is…
Groove Pancreatitis
Changes are centered around minor papilla and involve “groove” between pancreas and duodenum May mimic pancreatic neoplasm, including cystic neoplasm Microscopic • Duodenal wall around minor ampulla is thickened with marked…
Acinar Cell Cystadenoma
Reported range: 16-66 years • Benign cyst without risk of malignant transformation Macroscopic • Unilocular to multilocular thin-walled cyst(s) filled with serous fluid • Size range: 1.5-10.0 cm Microscopic • Cysts lined by single…
Idiopathic Adulthood Ductopenia
Biochemical evidence of cholestasis • Normal extrahepatic bile ducts • Variable prognosis, ranging from benign clinical course to progressive disease requiring liver transplantation Microscopic • Loss of interlobular bile ducts in > 50%…
Pancreatic Intraepithelial Neoplasia
Low grade includes PanIN-1 and PanIN-2 High grade includes PanIN-3 and carcinoma in situ • Low grade: Mild to moderate nuclear atypia • High grade: Marked nuclear atypia, loss of polarity, cribriforming,…
Inflammatory Polyps
Historically, these lesions have poorly defined histologic criteria and have been referred to by variety of names (e.g., fibroinflammatory polyp, fibroepithelial polyp, mucosal hyperplasia) Etiology/Pathogenesis • Probable result of mucosal injury…
Fatty Liver of Pregnancy
Some affected mothers and infants have inherited long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency Carnitine palmitoyltransferase I deficiency also associated with fatty liver of pregnancy Clinical Issues • Most commonly occurs in last…
Eosinophilic Cholecystitis
Probably not distinct entity, but rather descriptive designation with associated clinical correlates Etiology/Pathogenesis • Majority of cases have no known cause or disease association • Some associated with hypersensitivity reactions, parasitic infection,…
Bile Duct Adenoma
Often submitted for frozen section to rule out metastasis Microscopic • Uniformly sized tubules and acini with rounded outlines • Single layer of cuboidal to columnar cells that lack atypia, hyperchromasia, mitoses…
Gaucher Disease
Results in hepatosplenomegaly and pancytopenia • Variable disease progression • Enzyme replacement therapy represents mainstay therapy Early diagnosis is crucial to improving outcome Microscopic • Accumulation of glucocerebroside in Kupffer cells and portal…
