Abnormalities of the red cell membrane
CHAPTER 7 Abnormalities of the red cell membrane J. Delaunay Chapter contents HEREDITARY SPHEROCYTOSIS 115 ANK1 gene mutations 116 SLC4A1 gene mutations 116 SPTB gene mutations 118 EPB42 gene mutations…
Regulation of hematopoiesis
CHAPTER 4 Regulation of hematopoiesis SM. Buckley, C. Verfaillie Chapter contents INTRODUCTION 63 CHARACTERISTICS OF HEMATOPOIETIC STEM AND PROGENITOR CELLS 63 Phenotypic characterization 64 Functional characterization 64 HEMATOPOIETIC STEM CELL…
Data Management
2: Male9AgeDocument218–6599Age GroupRecode of Age11: 18–352: 36–503: 51–659FBSFasting Blood Glucose3Number 50–450999 Note that we have used 9, 99, and 999 as missing value codes. Such codes are common, but it…
Acquiring High Quality Data
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> 29 Acquiring High Quality Data The validity of a study depends on many things, from hypotheses that are based on sound science, to a study design…
Blinding in Observational Studies
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> 28 Blinding in Observational Studies Although blinding is typically thought of as something done in interventional studies, it can and should be used in observational studies…
Matching in Observational Studies
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> 27 Matching in Observational Studies In Sections 25.4 and 26.3.1 we described the use of multiple cohorts and multiple control groups, respectively. For cohort studies, cohort…
Participants in Case-Control Studies
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> 26 Participants in Case-Control Studies Case-control studies are designed to assess whether there is a link between one or more exposures and a particular outcome. The…
Defining Populations for Cohort Studies
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> 25 Defining Populations for Cohort Studies Chapter 6 presented an overview of cohort studies, which are observational studies of the relationship between exposures and outcomes in…
Adherence and Compliance
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> 24 Adherence and Compliance You, the investigator, want the participants to comply with your study procedures, which involves coming back for study visits as scheduled and…
Techniques to Blind Interventional Studies
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> 23 Techniques to Blind Interventional Studies In the previous chapter we described the purpose of blinding and the different levels used. In this chapter we describe…
