Fig. 4.1 Illustration of epigenetic structure in the mature sperm and the dramatic organization that occurs in the early embryo immediately following fertilization. The top panel shows the protamine-bound mature…
Fig. 6.1 The function of seminal fluid in the female reproductive tract following coitus. Seminal fluid exposure at coitus induces female responses that have consequences for conception and pregnancy. In…
Fig. 10.1 Hypothetical scenario on the immune modulatory capacity of seminal fluid. After contact with paternal antigens a rather tolerant immune response is generated. The graphic illustrates the interactions between…
Fig. 12.1 (a–d) Upper panel in each section shows chromosome profiles determined by partial genome sequencing. The lower panel in each section shows overlaid array CGH profile Partial Genome Sequencing:…
Before funding (%) After funding (%) # eSETs 1.6 49 % clinical pregnancy per embryo transfer 42.7 31 Multiple pregnancy rate 27.2 5.2 As these data suggest, an increased…
Fig. 17.1 Relational (Venn) diagram showing distribution of study patients and embryos In this study group, the mean (±SD) number of oocytes which underwent fertilization by ICSI was 17.7 ± 7.8 (range = 6–35),…
Fig. 5.1 The ‘two-step’ hypothesis on sperm DNA damage. Primary damage of the sperm DNA occurs in the testicle (1) as a result of uncompleted apoptosis, poor protamination, endogenous ‘nicks’,…
Control Extended sperm search of ejaculates (min) 30–60 61–120 121–180 >180 Cycles 3,559 55 27 5 2 [ ] × 103/ml 58,892 3,986 15.2 0.006 0.003 Sperm seen (range) 1–729 1–87…
Fig. 28.1 Maternal spindle transfer Fig. 28.2 Pronuclear transfer PNT is a similar process, but this time two embryos are initially created. A donor egg is first fertilised by the…
Fig. 21.1 Incremental cost-effectiveness ratios of embryo transfer policies for women <38. Notes: Whereas adjustments for inflation would move the ICER ratios upward on the y-axis, the relative difference in…
