Fig. 11.1 Long-term blockade of cocaine-primed reinstatement responding. CocH vector-treated rats (N = 14) made significantly fewer responses (# p < 0.05) on the lever previously paired with cocaine than control rats (N = 26) following…
© Springer International Publishing Switzerland 2016Ivan D. Montoya (ed.)Biologics to Treat Substance Use Disorders10.1007/978-3-319-23150-1_21 21. Ethical Considerations of Biologics to Treat Substance Use Disorders Ivan D. Montoya1 (1) Division of Therapeutics and Medical Consequences of Drug…
© Springer International Publishing Switzerland 2016Ivan D. Montoya (ed.)Biologics to Treat Substance Use Disorders10.1007/978-3-319-23150-1_1 1. Introduction: Biologics to Treat Substance Use Disorders: Vaccines, Monoclonal Antibodies, and Enzymes Phil Skolnick1 (1) Division of Pharmacotherapies and Medical…
, Berma M. Kinsey3, 4, Reetakshi Arora4, 5, Muthu Ramakrishnan3, 4 and Thomas R. Kosten6, 7 (1) Departments of Medicine, Pathology and Immunology, and Molecular Virology and Microbiology, Center for Translational Research in Inflammatory Diseases, Baylor…
Enzyme/antibody Km (μM) Kcat 3B9 490 0.11 min−1 15A10 220 2.3 min−1 BChE 38 1.2 min−1 Bacterial cocaine esterase 0.640 7.8 s−1 The catalytic antibody that received the most attention…
Fig. 5.1 Pooled antibody titer levels measured by ELISA on sera samples obtained from weeks 2 through 21 after the initial vaccination with SMA-TT with alum alone as adjuvant are…
© Springer International Publishing Switzerland 2016Ivan D. Montoya (ed.)Biologics to Treat Substance Use Disorders10.1007/978-3-319-23150-1_7 7. Monoclonal Antibodies S. Michael Owens1 (1) Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little…
© Springer International Publishing Switzerland 2016Ivan D. Montoya (ed.)Biologics to Treat Substance Use Disorders10.1007/978-3-319-23150-1_3 3. Vaccines for Treating Cocaine Use Disorders Coreen B. Domingo1, 2 , Daryl Shorter1, 2 and Thomas R. Kosten1, 2 (1) Michael E DeBakey Veterans Affairs…
Technique First used X-rays 1890s Computer Tomography (CT scan)a 1970s Single-photon emission computed tomography (SPECT) 1990s Electroencephalography (EEG) 1920s Brain Fingerprinting 1980s Positron Emission Tomography (PET) 1960s Magnetic Resonance…
Universe is deterministic? Yes No We possess free will? Yes Compatibilism (soft determinism) Libertarianism (Incompatibilism.1) No Hard determinism (Incompatibilism.2) Randoma aWhat is to be made of the fourth sector…
