Antimicrobial Susceptibility Testing of Anaerobic Bacteria
Resistance to β-lactam antibiotics can occur by one of three major mechanisms: inactivating enzymes (BLAs), low-affinity penicillin-binding proteins (PBPs), or decreased permeability. BLA is by far the most common mechanism…
that target protein synthesis
FIGURE 1 | The main steps of translation. FIGURE 2 | Crystal structure of three tRNA molecules interacting with an mRNA molecule and the 16s rRNA in the 30S ribosome…
Assessment of Bacterial Growth Inhibition by Optical Density Measurements
Figure 1 Schematic showing the mixed dispensability present in the biosynthetic pathways of many Gram-positive cell-wall surface polymers that are assembled on a bactoprenol carrier lipid and act as virulence…
and the Evolution of Antibiotic Resistance
Figure 1 Mechanisms of antibiotic resistance. Panel a, for inhibiting bacterial growth, an antibiotic (1), requires traverse the cellular envelopes either by specific transporters (2) or by diffusion through the…
Approaches to Bacterial Infection Therapy by Interfering with Cell-to-Cell Signaling
Figure 17.3.1 Generation of a reporter construct to identify inhibitors of cell-to-cell signaling. (A) This panel represents the native promoter and gene that is regulated by CCS. (B)This panel demonstrates…
Approaches to Antibiotic Drug Discovery
Figure 17.2.1 Pockets on the surface of a protein. For the color version of this figure, go to http://www.currentprotocols.com. Because many of these sites will be superfluous, it is important…
