Immunohistochemistry, Urinary Bladder Jesse K. McKenney, MD Rugvedita Parakh, MD Danielle E. Westfall, MD High-Grade Undifferentiated Carcinoma Antibody Prostate Urothelial PSA 68-94% 0% PAP 78-95% 0% PSMA > 95% (best)…
Invasive Squamous Cell Carcinoma Jesse K. McKenney, MD Key Facts Terminology Malignant epithelial neoplasm of bladder with pure squamous cell phenotype Etiology/Pathogenesis Chronic inflammatory conditions with squamous metaplasia are risk…
Prostatitis Gladell P. Paner, MD Key Facts Terminology Granulomatous prostatitis Inflammation of prostate containing granuloma Types: NSGP, postprocedural GP, IGP, systemic GP, xanthogranulomatous prostatitis Prostatitis syndrome Group of inflammatory and…
Clear Cell Adenocarcinoma Jesse K. McKenney, MD Key Facts Etiology/Pathogenesis Some cases arise in background of typical urothelial carcinoma Subset of CCC in females arise in association with endometriosis or…
Urachal Adenocarcinoma Jesse K. McKenney, MD Key Facts Terminology Primary carcinoma of any morphologic subtype originating from urachus Clinical Issues Very rare Hematuria is most common symptom Mucusuria rarely seen…
Squamous Proliferations Other than Carcinoma Jesse K. McKenney, MD Key Facts Etiology/Pathogenesis Keratinizing squamous metaplasia May be associated with chronic irritation Catheters, stones, or parasitic infection Neurogenic bladder Condyloma of…
Protocol for Urinary Bladder Cancer Specimens Urinary Bladder: Biopsy and Transurethral Resection of Bladder Tumor (TURBT) Surgical Pathology Cancer Case Summary (Checklist) Applies primarily to invasive carcinomas &/or associated epithelial…
Invasive Adenocarcinoma Jesse K. McKenney, MD Mahesha Vankalakunti, MD Key Facts Etiology/Pathogenesis Predisposing factors Associated with bladder exstrophy Nonfunctioning bladder Clinical Issues Rare primary bladder neoplasm (< 2% of bladder…
Invasive Urothelial Carcinoma Jesse K. McKenney, MD Key Facts Terminology Urothelial carcinoma that invades beyond basement membrane Clinical Issues Invasion into lamina propria usually managed with intravesical therapy Invasion into…
Cystitis Cystica and Glandularis Jesse K. McKenney, MD Key Facts Terminology Invaginated urothelial nests in superficial lamina propria with cystic dilatation forming luminal space Cystitis glandularis has luminal cuboidal or…
