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Nuchal-type Fibroma Brenda L. Nelson, DDS, MS Lester D. R. Thompson, MD Key Facts Terminology Benign, hyalinized, fibroblastic proliferation involving dermis and subcutis Clinical Issues Most common in posterior neck…

Paraganglioma (Glomus Jugulare/Tympanicum) Lester D. R. Thompson, MD Key Facts Terminology Synonyms: Glomus jugulare, glomus tympanicum Neoplasm arising from paraganglia in vicinity of jugular bulb or medial cochlea promontory Clinical…

Necrotizing Otitis Externa Bruce M. Wenig, MD Key Facts Etiology/Pathogenesis External otitis related to Pseudomonas aeruginosa infection Clinical Issues Diabetic, chronically debilitated, or immunologically deficient patients Primarily affects older patients…

Central Odontogenic Fibroma Brenda L. Nelson, DDS, MS Key Facts Terminology Rare, benign, odontogenic neoplasm of inactive-appearing odontogenic epithelium embedded in mature fibrous stroma Etiology/Pathogenesis Considered to be of periodontal…

Keratocystic Odontogenic Tumor (Odontogenic Keratocyst) Brenda L. Nelson, DDS, MS Key Facts Terminology Odontogenic keratocyst (OKC) Distinct developmental odontogenic cyst that may be locally aggressive Etiology/Pathogenesis Arise from cells of…

Carcinoma Ex-Pleomorphic Adenoma Lester D. R. Thompson, MD Key Facts Terminology Presence of carcinoma arising from pleomorphic adenoma Clinical Issues Usually 6th to 7th decades, about 10 years older than…

Protocol for the Examination of Salivary Gland Specimens Lester D. R. Thompson, MD Major Salivary Glands Incisional Biopsy, Excisional Biopsy, Resection Specimen ___ Parotid gland ___ Superficial lobe only ___…

Cystadenocarcinoma (Papillary) Lester D. R. Thompson, MD Key Facts Terminology Malignant epithelial salivary gland neoplasm characterized by predominantly cystic growth with intraluminal papillae Clinical Issues Slowly growing, painless swelling or…

Lymphoepithelial Carcinoma Bruce M. Wenig, MD Key Facts Terminology Undifferentiated carcinoma with associated prominent nonneoplastic lymphoplasmacytic cell infiltrate Etiology/Pathogenesis Etiology linked to Epstein-Barr virus (EBV) Near 100% association in patients…

Pleomorphic Adenoma Brenda L. Nelson, DDS, MS Key Facts Terminology Synonym: Benign mixed tumor Benign epithelial tumor that shows epithelial, myoepithelial, and mesenchymal differentiation Clinical Issues Most common neoplasm of…