Keratocystic Odontogenic Tumor (Odontogenic Keratocyst)



Keratocystic Odontogenic Tumor (Odontogenic Keratocyst)


Brenda L. Nelson, DDS, MS










Axial T2 MR reveals a mandibular odontogenic keratocyst as a high signal, expansile mass within the coronoid process image and ramus image. Internal septation image is noted.






Cells of the basal layer of the epithelium show characteristic palisading and hyperchromaticity image. The epithelium is 6-8 cells thick and demonstrates a wavy, parakeratinized surface image.


TERMINOLOGY


Synonyms



  • Odontogenic keratocyst (OKC)


  • Primordial cyst


  • Odontogenic keratocystoma


Definitions



  • Distinct developmental odontogenic cyst that may be locally aggressive


ETIOLOGY/PATHOGENESIS


Histogenesis



  • May arise from cells of dental lamina


  • May arise from extensions of basal cells from overlying oral epithelium


Inherited Condition



  • Nevoid basal cell carcinoma syndrome (NBCCS; Gorlin syndrome)



    • Autosomal dominant trait



      • High penetrance, variable expression


    • Spontaneous mutations


    • 9q22, involving PTCH gene


CLINICAL ISSUES


Epidemiology



  • Incidence



    • 4-12% of developmental cysts


  • Age



    • Wide range, usually 10-40 years


    • Cysts found at earlier age in those with NBCCS


  • Gender



    • Slight male predilection


  • Ethnicity



    • Caucasians affected most commonly

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Keratocystic Odontogenic Tumor (Odontogenic Keratocyst)

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