Portal Venous Obstruction
Portal Venous Obstruction Laura Webb Lamps, MD Key Facts Etiology/Pathogenesis Can occur at any level of portal venous system Extrahepatic: Portal trunk or large tributaries, usually caused by thrombosis Intrahepatic:…
Drug-related Steatohepatitis/Phospholipidosis
Drug-related Steatohepatitis/Phospholipidosis Laura Webb Lamps, MD Key Facts Terminology Definition: Steatohepatitis as consequence of drug exposure Etiology/Pathogenesis Commonly implicated drugs Amiodarone Methotrexate Antiretroviral drugs Nifedipine Clinical Issues Symptoms may present…
Drug-induced Acute Hepatic Failure
Drug-induced Acute Hepatic Failure Sanjay Kakar, MD Key Facts Terminology Onset of hepatic encephalopathy within 8 weeks of onset of symptoms INR is > 1.5, and there is no evidence…
Drug-related Granulomatous Hepatitis
Drug-related Granulomatous Hepatitis Laura Webb Lamps, MD Key Facts Clinical Issues Drug-induced hepatic injury can mimic any other form of liver disease Microscopic Pathology Noncaseating granulomas Presence of granulomas, ±…
Paucity of Intrahepatic Bile Ducts (Nonsyndromic)
Paucity of Intrahepatic Bile Ducts (Nonsyndromic) Joseph Misdraji, MD Key Facts Terminology Heterogeneous group of disorders that causes bile duct paucity in patients without congenital abnormalities indicative of Alagille syndrome…
Drug-related Acute Hepatitis
Drug-related Acute Hepatitis Sanjay Kakar, MD Key Facts Etiology/Pathogenesis 2 chief mechanisms: Intrinsic and idiosyncratic Herbal and botanical drugs are important but often overlooked cause of hepatotoxicity Clinical Issues Classified…
Idiopathic Adulthood Ductopenia
Idiopathic Adulthood Ductopenia Joseph Misdraji, MD Key Facts Terminology Ductopenia in adult without known cause or clinicopathologic features of specific etiology Clinical Issues Presents with episodic jaundice and pruritus Can…
Idiopathic Neonatal Hepatitis
Idiopathic Neonatal Hepatitis Grace E. Kim, MD Key Facts Terminology Convenient term for clinical condition manifested by prolonged jaundice in neonates with variable but definable histologic picture Microscopic Pathology Predominately…
Primary Biliary Cirrhosis
Primary Biliary Cirrhosis Matthew M. Yeh, MD, PhD Key Facts Terminology Idiopathic chronic cholestatic autoimmune liver disease in which intrahepatic bile ducts are progressively destroyed by nonsuppurative inflammation Clinical Issues…
