Sickle Cell Disease Anthony Chang, MD Key Facts Terminology Sickle cell nephropathy Etiology/Pathogenesis β-globin gene mutation Chromosome 11p15.5 Clinical Issues Presentation Chronic kidney disease Proteinuria Drugs Angiotensin-converting enzyme inhibitors Macroscopic…
Myeloma Cast Nephropathy Anthony Chang, MD Lynn D. Cornell, MD Key Facts Terminology Synonyms Light chain cast nephropathy Myeloma kidney Accumulation of monoclonal light chains may form casts (both cytotoxic…
Loin Pain Hematuria Syndrome Xin Gu, MD Key Facts Etiology/Pathogenesis Unknown or tubular obstruction from intranephron hemorrhage Clinical Issues LPHS is a diagnosis of exclusion Microscopic Pathology Normal or nonspecific…
Membranoproliferative Glomerulonephritis, Type I/III A. Brad Farris, III, MD Key Facts Terminology Subendothelial electron-dense deposits with mesangial interposition Clinical Issues Older children, adolescents, & young adults (˜ 7-30 years old)…
Aspergillosis Anthony Chang, MD Key Facts Etiology/Pathogenesis A. fumigatus A. flavus A. niger Clinical Issues Treatment Renal allograft nephrectomy Nephrostomy drainage and systemic antifungal therapy Voriconazole Incidence 0.1% in kidney…
Osmotic Tubulopathy Shane M. Meehan, MBBCh Key Facts Terminology Tubular epithelial swelling and isometric vacuolization, associated with exposure to parenteral carbohydrate solutions or contrast media, and acute kidney injury Etiology/Pathogenesis…
Microscopic Polyangiitis Surya V. Seshan, MD Key Facts Terminology Necrotizing vasculitis, with few or no immune deposits, affecting small arteries (capillaries, venules, or arterioles) Necrotizing glomerulonephritis is common Etiology/Pathogenesis ANCA-mediated…
Peritoneal/Omental Mass: Biopsy Peritoneal inclusion cysts are common incidental findings at the time of surgery. The cysts are usually translucent with a thin wall and filled with clear fluid. Larger…
Sarcoidosis Xin Gu, MD Key Facts Etiology/Pathogenesis Unclear etiology; disordered immune regulation Renal dysfunction related to nature and extent of involvement Clinical Issues More common in African-Americans than whites Involves…
Tuberous Sclerosis Aleksandr Vasilyev, MD, PhD Key Facts Etiology/Pathogenesis TSC1 gene, chromosome 9q34: Hamartin TSC2 gene, chromosome 16p13: Tuberin Chromosome 16p deletion may result in TSC2/PKD1 contiguous gene syndrome with…
