Alport Syndrome Helen Liapis, MD Joseph Gaut, MD, PhD Key Facts Etiology/Pathogenesis 85% X-linked inheritance of mutations in COL4A5 15% autosomal recessive COL4A3, COL4A4 Clinical Issues Presentation Hematuria, proteinuria, sensorineural…
Kidney, Adult: Diagnosis and Margins A nephrectomy removes the kidney, ureter, major vessels, and may remove the adrenal. Margins are rarely involved and intraoperative consultation is often not necessary. (Courtesy…
Systemic Lupus Erythematosus Shane M. Meehan, MBBCH Key Facts Terminology Systemic autoimmune disease manifested by inflammation of skin, joints, kidneys and central nervous system IgG autoantibodies to DNA, RNA, proteins,…
Idiopathic Nodular Glomerulopathy A. Brad Farris, III, MD Key Facts Terminology Idiopathic nodular glomerulopathy (ING)/glomerulosclerosis (GS) Nodular GS, associated with smoking &/or HTN without DM Etiology/Pathogenesis Smoking leads to physiologic…
HIV-associated Collapsing Glomerulopathy A. Brad Farris, III, MD Key Facts Clinical Issues Up to 90% of cases occur in African-American blacks, mostly male Rapid progression to ESRD Hypertension uncommon (in…
Hepatitis C Virus Anthony Chang, MD Key Facts Terminology Hepatitis C virus (HCV) Wide spectrum of immune complex-mediated glomerular injuries in association with HCV infection Clinical Issues Over 200 million…
Obstructive Nephropathy Sanjay Jain, MD, PhD Helen Liapis, MD Key Facts Terminology Acute or chronic damage to kidney due to obstruction of urine flow Etiology/Pathogenesis Many causes, congenital and acquired…
Nephrolithiasis Shane M. Meehan, MBBCh Key Facts Terminology Concretion of urinary mineral or inorganic crystals in kidney Etiology/Pathogenesis Causes 25% known cause 50% idiopathic hypercalciuria 25% unknown cause Clinical Issues…
Reflux Nephropathy Sanjay Jain, MD, PhD Helen Liapis, MD Key Facts Terminology Reflux nephropathy: Renal parenchymal scarring due to urine reflux Etiology/Pathogenesis Vesicoureteral reflux (VUR), UTIs Exposure of kidneys to…
