Suppurative Lymphadenitis C. Cameron Yin, MD, PhD Key Facts Terminology Acute lymphadenitis caused by bacterial, fungal, or some viral infections Etiology/Pathogenesis Common bacteria: Staphylococcus and Streptococcus Clinical Issues Regional lymph…
Reactive Paracortical Hyperplasia C. Cameron Yin, MD, PhD Key Facts Terminology Predominantly T-cell response commonly seen in viral and drug-related lymphadenopathies Clinical Issues Patients typically present with enlarged lymph nodes,…
Reactive Follicular Hyperplasia C. Cameron Yin, MD, PhD Key Facts Terminology Benign, reversible process characterized by hyperplastic secondary lymphoid follicles Clinical Issues Enlarged lymph nodes, localized or widespread ± systemic…
Oligomeganephronia Aleksandr Vasilyev, MD, PhD Key Facts Etiology/Pathogenesis Reduced nephron formation during development leads to nephron hypertrophy, secondary FSGS, and eventually ESRD Most cases sporadic, some related to mutations in…
Secondary Oxalosis Lynn D. Cornell, MD Key Facts Etiology/Pathogenesis Oxalate accumulation in kidney Enteric malabsorption (gastric bypass) Ingestion of oxalate-containing foods Pyridoxine deficiency Ingestion of ethylene glycol Clinical Issues Acute…
Primary Oxalosis Shane M. Meehan, MBBCh Key Facts Etiology/Pathogenesis Autosomal recessive mutations of AGT (PO1) or GR (PO2) genes Clinical Issues PO1: Hyperoxaluria (> 100 mg/d), increased urinary glycolate, renal…
Familial Juvenile Hyperuricemic Nephropathy Shane M. Meehan, MBBCh Key Facts Terminology Autosomal dominant tubulointerstitial disorder with chronic renal failure and hyperuricemia Etiology/Pathogenesis Mutations of uromodulin (UMOD) gene (on chromosome 16p12)…
Sjögren Syndrome Stephen M. Bonsib, MD Key Facts Terminology Progressive autoimmune disorder involving exocrine glands, particularly salivary and lacrimal glands May be primary or a component of other autoimmune disorders…
Antiviral Drug Nephrotoxicity Shane M. Meehan, MBBCh Key Facts Terminology Kidney dysfunction due to exposure to antiviral agents Etiology/Pathogenesis Direct tubular toxicity: Tenofovir, adefovir, acyclovir, cidofovir Tubulointerstitial nephritis (TIN): Indinavir,…
Balkan Endemic Nephropathy Shane M. Meehan, MBBCh Key Facts Etiology/Pathogenesis Environmental toxin(s) Aristolochic acid (AA) suspected Clinical Issues Slowly progressive renal failure in 30-50 year olds Impaired concentrating ability and…
