Oligomeganephronia



Oligomeganephronia


Aleksandr Vasilyev, MD, PhD










The hallmark of oligomeganephronia (OMN) is hypertrophy of the glomeruli due to a compensatory response to a congenital deficiency of nephrons. Glomeruli also have mesangial hypercellularity.






The tubules in OMN respond to congenitally decreased nephron numbers by increasing their diameter, as shown in these hypertrophied proximal tubules.


TERMINOLOGY


Abbreviations



  • Oligomeganephronia (OMN)


Synonyms



  • Oligomeganephronic hypoplasia


Definitions



  • Renal hypoplasia with marked compensatory nephron hypertrophy occurring both sporadically and due to specific genetic disorders


ETIOLOGY/PATHOGENESIS


Sporadic (Most Common)



  • Occasional PAX2 mutations, but in most cases etiology is unknown


  • Prematurity and low birth weight


Genetic Disorders (Rare)

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Oligomeganephronia
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