Mantle Cell Lymphoma, Blastoid Variant
Mantle Cell Lymphoma, Blastoid Variant C. Cameron Yin, MD, PhD Key Facts Terminology Highly aggressive subtype of mantle cell lymphoma composed of cells that resemble lymphoblasts (classic variant) or are…
Rheumatoid Arthritis-related Lymphadenopathy
Rheumatoid Arthritis-related Lymphadenopathy L. Jeffrey Medeiros, MD Key Facts Terminology Lymphadenopathy accompanying rheumatoid arthritis (RA) Etiology/Pathogenesis Smoking is risk factor Infectious agent may act as antigenic trigger of RA Genetic…
Hemophagocytic Lymphohistiocytosis
Hemophagocytic Lymphohistiocytosis Sa A. Wang, MD Key Facts Terminology Cytokine dysfunction, resulting in activation of T lymphocytes and macrophages Leads to systemic symptoms and organ damage Etiology/Pathogenesis Inherited genetic or…
Mantle Cell Lymphoma
Mantle Cell Lymphoma C Cameron Yin, MD, PhD Key Facts Terminology Clinically aggressive B-cell lymphoma associated with t(11;14)(q13;q32) and Cyclin-D1 overexpression Clinical Issues Elderly people; male predominance Most patients present…
Multicentric Castleman Disease
Multicentric Castleman Disease Pei Lin, MD Key Facts Terminology Systemic lymphoproliferative disease occurs in patients with immunodeficiency or immune dysregulation and is usually associated with human herpesvirus type 8 (HHV8)…
Lipid-associated Lymphadenopathy
Lipid-associated Lymphadenopathy Tariq Muzzafar, MBBS Key Facts Terminology Lymphadenopathy characterized by accumulation of endogenous or exogenous lipids Etiology/Pathogenesis Endogenous Diabetes mellitus, hyperlipidemia, hepatobiliary diseases Exogenous Total parenteral nutrition Mineral oil…
Unicentric Plasma Cell Variant Castleman Disease
Unicentric Plasma Cell Variant Castleman Disease Pei Lin, MD Key Facts Terminology Histologically distinctive reaction pattern in lymph node characterized by Marked interfollicular plasmacytosis Regressive (hyaline-vascular) changes in small subset…
Unicentric Hyaline Vascular Variant Castleman Disease
Unicentric Hyaline Vascular Variant Castleman Disease Pei Lin, MD Key Facts Clinical Issues Young adults Lymphadenopathy, localized Excision is usually curative Microscopic Pathology Large follicles with regressed (involuted) germinal centers…
Kikuchi-Fujimoto Disease
Kikuchi-Fujimoto Disease Carlos E. Bueso-Ramos, MD, PhD Key Facts Clinical Issues Self-limited clinical course in most patients Might represent phenotype of diverse disease entities Prognosis is different according to underlying…
Kimura Disease
Kimura Disease C. Cameron Yin, MD, PhD Key Facts Terminology Chronic inflammatory disease that affects subcutaneous tissue and regional lymph nodes Etiology/Pathogenesis Unknown; infectious cause suspected Clinical Issues Mainly in…
