Epithelial Cell Abnormalities: Squamous
Fig. 5.1 Nuclear area (LBP, ThinPrep). The nuclear area of an intermediate squamous cell is approximately 35 μm2. This is used as a reference to measure abnormal squamous cells such…
Non-Neoplastic Findings
Fig. 2.1 Superficial squamous cells (LBP, ThinPrep). Admixture of superficial and intermediate squamous cells. The superficial cells have smaller condensed (pyknotic) nuclei. Light brown glycogen is present in the cytoplasm…
Epithelial Abnormalities: Glandular
Fig. 6.1 Atypical endocervical cells, most likely from a reparative process (CP). Routine screen from a 39-year-old woman. Sheet of cells that demonstrate nuclear enlargement, increased nuclear to cytoplasmic (N/C)…
Atypical Squamous Cells
Fig. 4.1 ASC-US (LBP, ThinPrep). A 32-year-old woman. Atypical intermediate squamous cells with a nucleus 2−3× the area of a normal intermediate squamous cell nucleus and mild irregularity of nuclear…
Specimen Adequacy
Fig. 1.1 Unsatisfactory due to scant squamous cellularity. Endocervical cells are seen in a honeycomb arrangement (LBP, ThinPrep at 10× magnification) Fig. 1.2 Unsatisfactory – scant cellularity (LBP, SurePath). Although…
Other Malignant Neoplasms
Fig. 7.1 Spindle cell carcinoma (CP). Spindle-shaped nonkeratinizing cells displaying variability in nuclear size, nuclear membrane irregularity, coarse granular chromatin, and conspicuous nucleoli are arranged in a loosely cohesive cluster….
Anal Cytology
Fig. 8.1 Satisfactory specimen, negative for intraepithelial lesion (NILM) (LBP, SurePath). Benign intermediate type squamous cells, squamous metaplasia, and rectal columnar cells are present Fig. 8.2 Negative for intraepithelial lesion…
Endometrial Cells: The How and When of Reporting
Authors, year Definition of postmenopausal Cases with biopsy, n Hyperplasia, n (%) Cancer, n (%) Hyperplasia or cancer, n (%) Cherkis et al. (1988) [1] ≥40 179 23 (13) 20…
Risk Assessment Approach to Management
Fig. 12.1 Risk stratification and risk-based management. The absolute risk of disease is shown on the y-axis. A test or biomarker stratifies the population with a pretest risk into two…
Adjunctive Testing
Fig. 9.1 An example of cells from a high-grade squamous intraepithelial lesion from the same specimen: (a) Papanicolaou stain; (b) p16 immunocytochemical stain showing both nuclear and cytoplasmic staining. The…
